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2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+

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catalystActivity	[CatalystActivity:11338381] oxoglutarate dehydrogenase (NAD+) activity of OGDH complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11336135] Elser, Justin, 2025-03-26
dbId	11338383
displayName	2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+
eventOf	[Pathway:R-QLO-1119533] TCA cycle (plant) - Quercus lobata
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-QLO-1121627] succinyl-CoA + ADP + orthophosphate => succinate + ATP + CoA-SH - Quercus lobata
inferredFrom	[Reaction:R-OSA-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-QLO-1120194] isocitrate + NAD+ => 2-oxoglutarate + CO2 + NADH + H+ - Quercus lobata
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9823406] Quercus lobata
stId	R-QLO-1120492
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-QLO-1119533] TCA cycle (plant) - Quercus lobata
(precedingEvent)	[Reaction:R-QLO-1121627] succinyl-CoA + ADP + orthophosphate => succinate + ATP + CoA-SH - Quercus lobata
(inferredTo)	[Reaction:R-OSA-1120492] 2-oxoglutarate + coA-SH + NAD+ => succinyl-CoA + CO2 + NADH + H+ - Oryza sativa