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4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+

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catalystActivity	[CatalystActivity:11213137] C-4 methylsterol oxidase activity of Methylsterol monooxygenase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11212816] Elser, Justin, 2025-03-26
dbId	11216971
displayName	4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+
eventOf	[Pathway:R-PSO-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Papaver somniferum
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-PSO-1121645] 4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Papaver somniferum
inferredFrom	[Reaction:R-OSA-1120987] 4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Oryza sativa
input	[SimpleEntity:R-ALL-1132097] 4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol [cytosol] [DefinedSet:R-ALL-428206] NAD(P)H [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
name	4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ RXN66-21 biochemicalReaction85562
output	[SimpleEntity:R-ALL-1132271] 4alpha-formyl-5alpha-cholesta-8-en-3beta-ol [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-428218] NAD(P)+ [cytosol]
precedingEvent	[Reaction:R-PSO-1119821] 4alpha-methyl-cholesta-8-enol+O2+NAD(P)H->4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Papaver somniferum
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9764232] Papaver somniferum
stId	R-PSO-1120987
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-PSO-1119286] Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) - Papaver somniferum
(precedingEvent)	[Reaction:R-PSO-1121645] 4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Papaver somniferum
(inferredTo)	[Reaction:R-OSA-1120987] 4alpha-hydroxymethyl-5alpha-cholesta-8-en-3beta-ol+O2+NAD(P)H->4alpha-formyl-5alpha-cholesta-8-en-3beta-ol+H2O+NAD(P)+ - Oryza sativa