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Activation of pre-replication complex

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compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11325488] Elser, Justin, 2025-03-26
dbId	11335814
displayName	Activation of pre-replication complex
eventOf	[Pathway:R-PSA-9640887] G1/S transition - Pisum sativum
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Pathway:R-PSA-9675824] DNA replication Initiation - Pisum sativum
hasDiagram	false
hasEvent	[Reaction:R-PSA-9645961] Association of MCM10 with pre-replication complex - Pisum sativum [Reaction:R-PSA-9645867] Recruitment of CDC45 - Pisum sativum [Reaction:R-PSA-9645934] Association of TOPBP1 with CDC45 - Pisum sativum [Reaction:R-PSA-9645813] Binding of DNA polymerase alpha:primase at origin - Pisum sativum [Reaction:R-PSA-9645988] Binding of DNA polymerase epsilon at origin - Pisum sativum [Reaction:R-PSA-9645996] Displacement of CDC6 from pre-replication complex - Pisum sativum
inferredFrom	[Pathway:R-OSA-9645850] Activation of pre-replication complex - Oryza sativa
isInDisease	false
isInferred	true
name	Activation of pre-replication complex
precedingEvent	[Pathway:R-PSA-9640882] Assembly of pre-replication complex - Pisum sativum
releaseDate	2025-02-15
schemaClass	Pathway
species	[Species:9823412] Pisum sativum
stId	R-PSA-9645850
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(precedingEvent)	[Pathway:R-PSA-9675824] DNA replication Initiation - Pisum sativum
(hasEvent)	[Pathway:R-PSA-9640887] G1/S transition - Pisum sativum
(inferredTo)	[Pathway:R-OSA-9645850] Activation of pre-replication complex - Oryza sativa

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