Plant Reactome Pathway Database - Plant Reactome Pathway Database

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indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O

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catalystActivity	[CatalystActivity:1118851] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of YUCCA like [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2744267] D'Eustachio, P, 2012-12-05
crossReference	[DatabaseIdentifier:1154278] EC-NUMBER:1.14.13.-
dbId	2744287
displayName	indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O
eventOf	[Pathway:R-OSA-1119486] IAA biosynthesis I - Oryza sativa
evidenceType	[EvidenceType:1112911] IEA
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1132125] indole-3-pyruvate [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2744298] The pathway of auxin biosynthesis in plants
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O
orthologousEvent	[Reaction:R-BRA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Brassica rapa [Reaction:R-CQI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Chenopodium quinoa [Reaction:R-PPE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Prunus persica [Reaction:R-CCL-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Citrus clementina [Reaction:R-GSO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Glycine soja [Reaction:R-PED-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Phyllostachys edulis [Reaction:R-VUN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Vigna unguiculata [Reaction:R-ATR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Amborella trichopoda [Reaction:R-PPA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Physcomitrella patens [Reaction:R-TCA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Theobroma cacao [Reaction:R-CCP-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Corchorus capsularis [Reaction:R-PAV-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Prunus avium [Reaction:R-OKA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza sativa aus subgroup [Reaction:R-OBA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza barthii [Reaction:R-HAN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Helianthus annuus [Reaction:R-ECU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Eragrostis curvula [Reaction:R-STU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Solanum tuberosum [Reaction:R-SIN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Sesamum indicum [Reaction:R-DCA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Daucus carota [Reaction:R-PAB-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Picea abies [Reaction:R-SSP-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Saccharum spontaneum [Reaction:R-CRU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Capsella rubella [Reaction:R-BDI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Brachypodium distachyon [Reaction:R-PVE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Pistacia vera [Reaction:R-CSI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Citrus sinensis [Reaction:R-SHI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Salvia hispanica [Reaction:R-BVU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Beta vulgaris [Reaction:R-BNA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Brassica napus [Reaction:R-MGU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Erythranthe guttata [Reaction:R-JCU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Jatropha curcas [Reaction:R-TTI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum timopheevii subsp. timopheevii [Reaction:R-TTU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum turgidum [Reaction:R-ONI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza nivara [Reaction:R-OMI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza minuta [Reaction:R-OBR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza brachyantha [Reaction:R-DEX-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Digitaria exilis [Reaction:R-PDA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Phoenix dactylifera [Reaction:R-MDO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Malus domestica [Reaction:R-GRA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Gossypium raimondii [Reaction:R-ITR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Ipomoea triloba [Reaction:R-ALY-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arabidopsis lyrata [Reaction:R-TSP-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum spelta subsp. spelta [Reaction:R-FVE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Fragaria vesca [Reaction:R-CCD-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cynara cardunculus var. scolymus [Reaction:R-PSO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Papaver somniferum [Reaction:R-VVN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Vitis vinifera [Reaction:R-AIP-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arachis ipaensis [Reaction:R-OGU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza glumaepatula [Reaction:R-OSI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza sativa Indica Group [Reaction:R-FCR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Ficus carica [Reaction:R-ATH-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arabidopsis thaliana [Reaction:R-DRO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Dioscorea rotundata [Reaction:R-MTR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Medicago truncatula [Reaction:R-TDI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum dicoccoides [Reaction:R-QSU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Quercus suber [Reaction:R-ZJA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Zoysia japonica [Reaction:R-OLO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza longistaminata [Reaction:R-NNU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Nelumbo nucifera [Reaction:R-CAR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cicer arietinum [Reaction:R-TPR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Trifolium pratense [Reaction:R-OPU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza punctata [Reaction:R-AHA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arabidopsis halleri [Reaction:R-SCR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Secale cereale [Reaction:R-ZMA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Zea mays [Reaction:R-MAC-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Musa acuminata [Reaction:R-CSA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cucumis sativus [Reaction:R-AHY-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arachis hypogaea [Reaction:R-ETE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Eragrostis tef [Reaction:R-OME-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza meridionalis [Reaction:R-FEX-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Fraxinus excelsior (European ash) [Reaction:R-VAN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Vigna angularis [Reaction:R-ORU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza rufipogon [Reaction:R-CCI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Corymbia citriodora [Reaction:R-BOL-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Brassica oleracea [Reaction:R-HLP-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Humulus lupulus var. lupulus [Reaction:R-ACO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Ananas comosus [Reaction:R-PSA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Pisum sativum [Reaction:R-HVU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Hordeum vulgare [Reaction:R-VRA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Vigna radiata [Reaction:R-RCH-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Rosa chinensis [Reaction:R-PVU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Phaseolus vulgaris [Reaction:R-EGR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Eucalyptus grandis [Reaction:R-ECG-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Echinochloa crus-galli [Reaction:R-VFA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Vicia faba var. faba [Reaction:R-GMA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Glycine max [Reaction:R-CML-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cucumis melo [Reaction:R-ACH-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Actinidia chinensis [Reaction:R-LST-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Lathyrus sativus [Reaction:R-COL-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Corchorus olitorius [Reaction:R-LPE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Leersia perrieri [Reaction:R-ATA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Aegilops tauschii [Reaction:R-PTA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Pinus taeda [Reaction:R-CSK-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cannabis sativa subsp. indica [Reaction:R-PHA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Panicum hallii ("FIL2") [Reaction:R-ADU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Arachis duranensis [Reaction:R-CCA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cajanus cajan [Reaction:R-LPR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Lolium perenne [Reaction:R-PTI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Populus trichocarpa [Reaction:R-ASA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Avena sativa [Reaction:R-OOF-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza officinalis [Reaction:R-SPC-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Synechocystis sp. PCC 6803 [Reaction:R-LSA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Lactuca sativa [Reaction:R-OAU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza australiensis [Reaction:R-LAN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Lupinus angustifolius [Reaction:R-MES-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Manihot esculenta [Reaction:R-OGR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza meyeriana var. granulata [Reaction:R-AOF-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Asparagus officinalis [Reaction:R-CAN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Capsicum annuum [Reaction:R-OEU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Olea europaea [Reaction:R-CST-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Camelina sativa [Reaction:R-TUR-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum urartu [Reaction:R-ZMY-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Zea mays ver5 [Reaction:R-CSC-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Cannabis sativa [Reaction:R-SBI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Sorghum bicolor [Reaction:R-PHH-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Panicum hallii var. hallii ("HAL2") [Reaction:R-JRE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Juglans regia [Reaction:R-QLO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Quercus lobata [Reaction:R-SMO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Selaginella moellendorffii [Reaction:R-NAT-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Nicotiana attenuata [Reaction:R-OGL-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Oryza glaberrima [Reaction:R-NCO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Nymphaea colorata [Reaction:R-SVI-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Setaria viridis [Reaction:R-BJU-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Brassica juncea [Reaction:R-SIT-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Setaria italica [Reaction:R-MPO-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Marchantia polymorpha [Reaction:R-SLY-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Solanum lycopersicum [Reaction:R-OES-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Olea europaea var. sylvestris [Reaction:R-CLA-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Citrullus lanatus [Reaction:R-CCN-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Coffea canephora [Reaction:R-AUM-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Aegilops umbellulata [Reaction:R-TAE-2744287] indole-3-pyruvate+O2+NADPH+H+->indole-3-acetate+CO2+NADP++H2O - Triticum aestivum
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1131161] IAA [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
reviewed	[InstanceEdit:2744296] Amarasinghe, V, 2012-11-29
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-2744287
summation	[Summation:2744276] A flavin monooxygenase-like enzyme (YUCCA like) converts Ind...

Referrals

(hasEvent)

[Pathway:R-OSA-1119486] IAA biosynthesis I - Oryza sativa