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2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+

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catalystActivity	[CatalystActivity:2851766] 2'-hydroxyisoflavone reductase activity of 2'-hydroxyisoflavone reductase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1154400] EC-NUMBER:1.3.1.45 [DatabaseIdentifier:1133276] RiceCyc:RXN-3562
dbId	1120912
displayName	2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+
eventOf	[Pathway:R-OSA-1119453] Medicarpin biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1120148] (-)-vestitone+NADPH+H+->7,2'-dihydroxy-4'-methoxy-isoflavanol+NADP+ - Oryza sativa
input	[SimpleEntity:R-ALL-1132284] 2-hydroxyformononetin [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11529250] Elser, Justin, 2025-03-27
name	2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ RXN-3562 biochemicalReaction81096
orthologousEvent	[Reaction:R-SIT-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Setaria italica [Reaction:R-TCA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Theobroma cacao [Reaction:R-HLP-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Humulus lupulus var. lupulus [Reaction:R-PTI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Populus trichocarpa [Reaction:R-OLO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza longistaminata [Reaction:R-CSK-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cannabis sativa subsp. indica [Reaction:R-CSC-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cannabis sativa [Reaction:R-NCO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Nymphaea colorata [Reaction:R-GSO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Glycine soja [Reaction:R-CCP-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Corchorus capsularis [Reaction:R-LSA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Lactuca sativa [Reaction:R-ADU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arachis duranensis [Reaction:R-PED-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Phyllostachys edulis [Reaction:R-GRA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Gossypium raimondii [Reaction:R-EGR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Eucalyptus grandis [Reaction:R-CML-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cucumis melo [Reaction:R-HLH-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Humulus lupulus [Reaction:R-OPU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza punctata [Reaction:R-PAV-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Prunus avium [Reaction:R-ZMA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Zea mays [Reaction:R-JRE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Juglans regia [Reaction:R-CCA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cajanus cajan [Reaction:R-PHH-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Panicum hallii var. hallii ("HAL2") [Reaction:R-CCD-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cynara cardunculus var. scolymus [Reaction:R-QLO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Quercus lobata [Reaction:R-STU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Solanum tuberosum [Reaction:R-TAE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum aestivum [Reaction:R-OSI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza sativa Indica Group [Reaction:R-TDI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum dicoccoides [Reaction:R-OGU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza glumaepatula [Reaction:R-RCH-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Rosa chinensis [Reaction:R-CAR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cicer arietinum [Reaction:R-GMA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Glycine max [Reaction:R-ONI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza nivara [Reaction:R-BVU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Beta vulgaris [Reaction:R-ECU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Eragrostis curvula [Reaction:R-OES-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Olea europaea var. sylvestris [Reaction:R-FVE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Fragaria vesca [Reaction:R-FCR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Ficus carica [Reaction:R-ITR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Ipomoea triloba [Reaction:R-CAN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Capsicum annuum [Reaction:R-SLY-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Solanum lycopersicum [Reaction:R-PVU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Phaseolus vulgaris [Reaction:R-LST-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Lathyrus sativus [Reaction:R-FEX-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Fraxinus excelsior (European ash) [Reaction:R-PPE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Prunus persica [Reaction:R-TPR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Trifolium pratense [Reaction:R-TSP-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum spelta subsp. spelta [Reaction:R-DEX-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Digitaria exilis [Reaction:R-CCN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Coffea canephora [Reaction:R-VVN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Vitis vinifera [Reaction:R-MDO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Malus domestica [Reaction:R-CCI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Corymbia citriodora [Reaction:R-SMO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Selaginella moellendorffii [Reaction:R-VUN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Vigna unguiculata [Reaction:R-JCU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Jatropha curcas [Reaction:R-AOF-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Asparagus officinalis [Reaction:R-PSO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Papaver somniferum [Reaction:R-ALY-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arabidopsis lyrata [Reaction:R-HAN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Helianthus annuus [Reaction:R-HVU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Hordeum vulgare [Reaction:R-BNA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Brassica napus [Reaction:R-LPE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Leersia perrieri [Reaction:R-CST-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Camelina sativa [Reaction:R-OMI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza minuta [Reaction:R-BJU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Brassica juncea [Reaction:R-CQI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Chenopodium quinoa [Reaction:R-SCR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Secale cereale [Reaction:R-SVI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Setaria viridis [Reaction:R-NNU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Nelumbo nucifera [Reaction:R-CLA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Citrullus lanatus [Reaction:R-NAT-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Nicotiana attenuata [Reaction:R-DRO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Dioscorea rotundata [Reaction:R-BRA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Brassica rapa [Reaction:R-OKA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza sativa aus subgroup [Reaction:R-AHA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arabidopsis halleri [Reaction:R-LAN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Lupinus angustifolius [Reaction:R-OAU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza australiensis [Reaction:R-ATR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Amborella trichopoda [Reaction:R-ECG-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Echinochloa crus-galli [Reaction:R-OEU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Olea europaea [Reaction:R-MES-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Manihot esculenta [Reaction:R-AHY-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arachis hypogaea [Reaction:R-ATA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Aegilops tauschii [Reaction:R-CSI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Citrus sinensis [Reaction:R-ZJA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Zoysia japonica [Reaction:R-OBA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza barthii [Reaction:R-OOF-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza officinalis [Reaction:R-TTU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum turgidum [Reaction:R-PDA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Phoenix dactylifera [Reaction:R-MGU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Erythranthe guttata [Reaction:R-AUM-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Aegilops umbellulata [Reaction:R-CCL-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Citrus clementina [Reaction:R-VFA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Vicia faba var. faba [Reaction:R-MTR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Medicago truncatula [Reaction:R-DCA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Daucus carota [Reaction:R-CRU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Capsella rubella [Reaction:R-TUR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum urartu [Reaction:R-VRA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Vigna radiata [Reaction:R-MPO-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Marchantia polymorpha [Reaction:R-SBI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Sorghum bicolor [Reaction:R-PTA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Pinus taeda [Reaction:R-AIP-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arachis ipaensis [Reaction:R-QSU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Quercus suber [Reaction:R-OBR-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza brachyantha [Reaction:R-PVE-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Pistacia vera [Reaction:R-PAB-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Picea abies [Reaction:R-VAN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Vigna angularis [Reaction:R-ACH-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Actinidia chinensis [Reaction:R-PHA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Panicum hallii ("FIL2") [Reaction:R-CSA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Cucumis sativus [Reaction:R-ORU-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza rufipogon [Reaction:R-COL-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Corchorus olitorius [Reaction:R-TTI-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Triticum timopheevii subsp. timopheevii [Reaction:R-ATH-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Arabidopsis thaliana [Reaction:R-OGL-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Oryza glaberrima [Reaction:R-SSP-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Saccharum spontaneum [Reaction:R-BOL-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Brassica oleracea [Reaction:R-PSA-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Pisum sativum [Reaction:R-SIN-1120912] 2-hydroxyformononetin+NADPH->(-)-vestitone+NADP+ - Sesamum indicum
output	[SimpleEntity:R-ALL-1130892] (-)-vestitone [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-OSA-1120758] Isoflavone 2'-hydroxylase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120912
summation	[Summation:2851763] 2-hydroxyformononetin is converted to (-)-vestitone by a set...

Referrals

(hasEvent)	[Pathway:R-OSA-1119453] Medicarpin biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120148] (-)-vestitone+NADPH+H+->7,2'-dihydroxy-4'-methoxy-isoflavanol+NADP+ - Oryza sativa