Plant Reactome Pathway Database - Plant Reactome Pathway Database

Schema > Reaction > Entries

dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O

Go to Details

catalystActivity	[CatalystActivity:1118404] flavonoid 3'-monooxygenase activity of flavonoid-3-hydroxylase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:1142404] RiceCyc:RXN-525
dbId	1120654
displayName	dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O
eventOf	[Pathway:R-OSA-1119415] Leucopelargonidin and leucocyanidin biosynthesis - Oryza sativa [Pathway:R-OSA-1119322] Leucodelphinidin biosynthesis - Oryza sativa
followingEvent	[Reaction:R-OSA-1121463] dihydroquercetin+NADPH+O2->a hydroxyflavonone+dihydromyricetin+NADP++H2O - Oryza sativa [Reaction:R-OSA-1120439] dihydroquercetin+NADPH->leucocyanidin+NADP+ - Oryza sativa
input	[SimpleEntity:R-ALL-1130854] dihydrokaempferol [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O RXN-525 biochemicalReaction86034
orthologousEvent	[Reaction:R-FEX-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Fraxinus excelsior (European ash) [Reaction:R-PSA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Pisum sativum [Reaction:R-OAU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza australiensis [Reaction:R-TCA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Theobroma cacao [Reaction:R-DEX-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Digitaria exilis [Reaction:R-DCA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Daucus carota [Reaction:R-ALY-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arabidopsis lyrata [Reaction:R-EGR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Eucalyptus grandis [Reaction:R-ZMA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Zea mays [Reaction:R-VRA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Vigna radiata [Reaction:R-TPR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Trifolium pratense [Reaction:R-TSP-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum spelta subsp. spelta [Reaction:R-SIN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Sesamum indicum [Reaction:R-MAC-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Musa acuminata [Reaction:R-HLH-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Humulus lupulus [Reaction:R-LST-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Lathyrus sativus [Reaction:R-CSI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Citrus sinensis [Reaction:R-AHA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arabidopsis halleri [Reaction:R-PAV-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Prunus avium [Reaction:R-PVE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Pistacia vera [Reaction:R-PTA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Pinus taeda [Reaction:R-PSO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Papaver somniferum [Reaction:R-OBA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza barthii [Reaction:R-MTR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Medicago truncatula [Reaction:R-CAN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Capsicum annuum [Reaction:R-ATA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Aegilops tauschii [Reaction:R-CCA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cajanus cajan [Reaction:R-LSA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Lactuca sativa [Reaction:R-BDI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Brachypodium distachyon [Reaction:R-SVI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Setaria viridis [Reaction:R-ATH-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arabidopsis thaliana [Reaction:R-CSK-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cannabis sativa subsp. indica [Reaction:R-ZMY-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Zea mays ver5 [Reaction:R-OSI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza sativa Indica Group [Reaction:R-ITR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Ipomoea triloba [Reaction:R-CML-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cucumis melo [Reaction:R-ECG-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Echinochloa crus-galli [Reaction:R-OEU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Olea europaea [Reaction:R-BJU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Brassica juncea [Reaction:R-CLA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Citrullus lanatus [Reaction:R-TAE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum aestivum [Reaction:R-BRA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Brassica rapa [Reaction:R-VVN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Vitis vinifera [Reaction:R-PHA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Panicum hallii ("FIL2") [Reaction:R-OOF-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza officinalis [Reaction:R-OMI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza minuta [Reaction:R-TTI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum timopheevii subsp. timopheevii [Reaction:R-AUM-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Aegilops umbellulata [Reaction:R-NAT-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Nicotiana attenuata [Reaction:R-CCI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Corymbia citriodora [Reaction:R-BNA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Brassica napus [Reaction:R-LAN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Lupinus angustifolius [Reaction:R-VUN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Vigna unguiculata [Reaction:R-HVU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Hordeum vulgare [Reaction:R-GMA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Glycine max [Reaction:R-ECU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Eragrostis curvula [Reaction:R-OGU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza glumaepatula [Reaction:R-ACH-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Actinidia chinensis [Reaction:R-SIT-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Setaria italica [Reaction:R-CST-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Camelina sativa [Reaction:R-JRE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Juglans regia [Reaction:R-QLO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Quercus lobata [Reaction:R-ASA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Avena sativa [Reaction:R-NNU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Nelumbo nucifera [Reaction:R-ORU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza rufipogon [Reaction:R-CAR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cicer arietinum [Reaction:R-STU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Solanum tuberosum [Reaction:R-BOL-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Brassica oleracea [Reaction:R-OES-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Olea europaea var. sylvestris [Reaction:R-PVU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Phaseolus vulgaris [Reaction:R-PAB-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Picea abies [Reaction:R-HAN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Helianthus annuus [Reaction:R-ONI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza nivara [Reaction:R-SCR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Secale cereale [Reaction:R-CCP-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Corchorus capsularis [Reaction:R-CSC-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cannabis sativa [Reaction:R-MDO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Malus domestica [Reaction:R-SBI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Sorghum bicolor [Reaction:R-CSA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cucumis sativus [Reaction:R-LPR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Lolium perenne [Reaction:R-ATR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Amborella trichopoda [Reaction:R-VAN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Vigna angularis [Reaction:R-OGR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza meyeriana var. granulata [Reaction:R-SLY-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Solanum lycopersicum [Reaction:R-ADU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arachis duranensis [Reaction:R-ETE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Eragrostis tef [Reaction:R-PDA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Phoenix dactylifera [Reaction:R-VFA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Vicia faba var. faba [Reaction:R-MGU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Erythranthe guttata [Reaction:R-OBR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza brachyantha [Reaction:R-FCR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Ficus carica [Reaction:R-TDI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum dicoccoides [Reaction:R-ACO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Ananas comosus [Reaction:R-JCU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Jatropha curcas [Reaction:R-COL-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Corchorus olitorius [Reaction:R-CCL-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Citrus clementina [Reaction:R-GSO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Glycine soja [Reaction:R-OPU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza punctata [Reaction:R-GRA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Gossypium raimondii [Reaction:R-PED-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Phyllostachys edulis [Reaction:R-NCO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Nymphaea colorata [Reaction:R-HLP-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Humulus lupulus var. lupulus [Reaction:R-AIP-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arachis ipaensis [Reaction:R-TUR-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum urartu [Reaction:R-QSU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Quercus suber [Reaction:R-CCN-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Coffea canephora [Reaction:R-AHY-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Arachis hypogaea [Reaction:R-FVE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Fragaria vesca [Reaction:R-PTI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Populus trichocarpa [Reaction:R-SHI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Salvia hispanica [Reaction:R-DRO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Dioscorea rotundata [Reaction:R-OKA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza sativa aus subgroup [Reaction:R-OLO-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza longistaminata [Reaction:R-AOF-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Asparagus officinalis [Reaction:R-PPE-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Prunus persica [Reaction:R-OGL-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Oryza glaberrima [Reaction:R-BVU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Beta vulgaris [Reaction:R-MES-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Manihot esculenta [Reaction:R-PHH-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Panicum hallii var. hallii ("HAL2") [Reaction:R-CCD-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Cynara cardunculus var. scolymus [Reaction:R-RCH-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Rosa chinensis [Reaction:R-CRU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Capsella rubella [Reaction:R-CQI-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Chenopodium quinoa [Reaction:R-TTU-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Triticum turgidum [Reaction:R-ZJA-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Zoysia japonica [Reaction:R-SSP-1120654] dihydrokaempferol + NADPH + H+ + O2 -> dihydroquercetin + NADP+ + H2O - Saccharum spontaneum
output	[SimpleEntity:R-ALL-1132258] dihydroquercetin [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120654
summation	[Summation:2672436] Dihydrokaempferol is converted into dihydroquercetin by enzy... [Summation:1251362] dihydrokaempferol + NADPH + H+ + O2 + H+ <=> dihydroquercet...

Referrals

(hasEvent)	[Pathway:R-OSA-1119322] Leucodelphinidin biosynthesis - Oryza sativa [Pathway:R-OSA-1119415] Leucopelargonidin and leucocyanidin biosynthesis - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1121463] dihydroquercetin+NADPH+O2->a hydroxyflavonone+dihydromyricetin+NADP++H2O - Oryza sativa [Reaction:R-OSA-1120439] dihydroquercetin+NADPH->leucocyanidin+NADP+ - Oryza sativa

© 2019 Gramene - Plant Reactome