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5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase

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catalystActivity	[CatalystActivity:1118288] 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity of 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26936] EC:2.1.1.14 [DatabaseIdentifier:1133610] RiceCyc:HOMOCYSMET-RXN
dbId	1120370
displayName	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
eventOf	[Pathway:R-OSA-1119501] S-adenosyl-L-methionine cycle - Oryza sativa [Pathway:R-OSA-1119400] Methionine biosynthesis II - Oryza sativa
followingEvent	[Reaction:R-OSA-1121647] Methionine adenosyltransferase - Oryza sativa
input	[SimpleEntity:R-ALL-4789072] 5-methyltetrahydropteroyltri-L-glutamate [cytosol] [SimpleEntity:R-ALL-1131040] LHCYS [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Tetrahydropteroyltriglutamate methyltransferase Methionine synthase biochemicalReaction77412
orthologousEvent	[Reaction:R-TSP-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum spelta subsp. spelta [Reaction:R-CME-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cyanidioschyzon merolae [Reaction:R-ATR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Amborella trichopoda [Reaction:R-ZMY-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Zea mays ver5 [Reaction:R-LSA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Lactuca sativa [Reaction:R-OPU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza punctata [Reaction:R-BVU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Beta vulgaris [Reaction:R-FVE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Fragaria vesca [Reaction:R-PTI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Populus trichocarpa [Reaction:R-NAT-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Nicotiana attenuata [Reaction:R-TTI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum timopheevii subsp. timopheevii [Reaction:R-CCD-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cynara cardunculus var. scolymus [Reaction:R-SIN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Sesamum indicum [Reaction:R-PDA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Phoenix dactylifera [Reaction:R-CRE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Chlamydomonas reinhardtii [Reaction:R-SBI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Sorghum bicolor [Reaction:R-BJU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Brassica juncea [Reaction:R-OGR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza meyeriana var. granulata [Reaction:R-ITR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Ipomoea triloba [Reaction:R-CAR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cicer arietinum [Reaction:R-TPR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Trifolium pratense [Reaction:R-VAN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Vigna angularis [Reaction:R-DRO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Dioscorea rotundata [Reaction:R-TDI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum dicoccoides [Reaction:R-OES-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Olea europaea var. sylvestris [Reaction:R-CCN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Coffea canephora [Reaction:R-STU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Solanum tuberosum [Reaction:R-CML-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cucumis melo [Reaction:R-PPA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Physcomitrella patens [Reaction:R-ECG-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Echinochloa crus-galli [Reaction:R-MTR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Medicago truncatula [Reaction:R-BDI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Brachypodium distachyon [Reaction:R-CLA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Citrullus lanatus [Reaction:R-CCP-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Corchorus capsularis [Reaction:R-BOL-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Brassica oleracea [Reaction:R-ACO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Ananas comosus [Reaction:R-AIP-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arachis ipaensis [Reaction:R-OME-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza meridionalis [Reaction:R-OGL-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza glaberrima [Reaction:R-BRA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Brassica rapa [Reaction:R-VUN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Vigna unguiculata [Reaction:R-CCI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Corymbia citriodora [Reaction:R-EGR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Eucalyptus grandis [Reaction:R-PSA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Pisum sativum [Reaction:R-VFA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Vicia faba var. faba [Reaction:R-RCH-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Rosa chinensis [Reaction:R-PHH-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Panicum hallii var. hallii ("HAL2") [Reaction:R-MES-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Manihot esculenta [Reaction:R-OSI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza sativa Indica Group [Reaction:R-AHY-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arachis hypogaea [Reaction:R-HVU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Hordeum vulgare [Reaction:R-GSU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Galdieria sulphuraria [Reaction:R-CSC-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cannabis sativa [Reaction:R-PVU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Phaseolus vulgaris [Reaction:R-HAN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Helianthus annuus [Reaction:R-ALY-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arabidopsis lyrata [Reaction:R-PAB-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Picea abies [Reaction:R-AOF-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Asparagus officinalis [Reaction:R-ECU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Eragrostis curvula [Reaction:R-ETE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Eragrostis tef [Reaction:R-CRU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Capsella rubella [Reaction:R-ZMA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Zea mays [Reaction:R-CQI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Chenopodium quinoa [Reaction:R-TAE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum aestivum [Reaction:R-QSU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Quercus suber [Reaction:R-AHA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arabidopsis halleri [Reaction:R-TTU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum turgidum [Reaction:R-GSO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Glycine soja [Reaction:R-ACH-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Actinidia chinensis [Reaction:R-CSK-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cannabis sativa subsp. indica [Reaction:R-PED-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Phyllostachys edulis [Reaction:R-PHA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Panicum hallii ("FIL2") [Reaction:R-DEX-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Digitaria exilis [Reaction:R-OEU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Olea europaea [Reaction:R-SIT-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Setaria italica [Reaction:R-CST-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Camelina sativa [Reaction:R-CSI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Citrus sinensis [Reaction:R-PSO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Papaver somniferum [Reaction:R-QLO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Quercus lobata [Reaction:R-COL-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Corchorus olitorius [Reaction:R-MPO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Marchantia polymorpha [Reaction:R-HLP-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Humulus lupulus var. lupulus [Reaction:R-CCR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Chondrus crispus [Reaction:R-SMO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Selaginella moellendorffii [Reaction:R-MAC-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Musa acuminata [Reaction:R-VVN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Vitis vinifera [Reaction:R-ADU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arachis duranensis [Reaction:R-TUR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Triticum urartu [Reaction:R-GRA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Gossypium raimondii [Reaction:R-BNA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Brassica napus [Reaction:R-OOF-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza officinalis [Reaction:R-LPE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Leersia perrieri [Reaction:R-CSA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cucumis sativus [Reaction:R-OLO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza longistaminata [Reaction:R-LST-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Lathyrus sativus [Reaction:R-SVI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Setaria viridis [Reaction:R-JCU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Jatropha curcas [Reaction:R-SSP-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Saccharum spontaneum [Reaction:R-AUM-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Aegilops umbellulata [Reaction:R-JRE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Juglans regia [Reaction:R-OAU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza australiensis [Reaction:R-LAN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Lupinus angustifolius [Reaction:R-VRA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Vigna radiata [Reaction:R-PTA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Pinus taeda [Reaction:R-PPE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Prunus persica [Reaction:R-FCR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Ficus carica [Reaction:R-CCA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Cajanus cajan [Reaction:R-FEX-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Fraxinus excelsior (European ash) [Reaction:R-SCR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Secale cereale [Reaction:R-MGU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Erythranthe guttata [Reaction:R-TCA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Theobroma cacao [Reaction:R-NCO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Nymphaea colorata [Reaction:R-OGU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza glumaepatula [Reaction:R-HLH-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Humulus lupulus [Reaction:R-SLY-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Solanum lycopersicum [Reaction:R-ZJA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Zoysia japonica [Reaction:R-ASA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Avena sativa [Reaction:R-SHI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Salvia hispanica [Reaction:R-ATA-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Aegilops tauschii [Reaction:R-CCL-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Citrus clementina [Reaction:R-PAV-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Prunus avium [Reaction:R-PVE-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Pistacia vera [Reaction:R-OBR-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza brachyantha [Reaction:R-OMI-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Oryza minuta [Reaction:R-CAN-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Capsicum annuum [Reaction:R-MDO-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Malus domestica [Reaction:R-NNU-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Nelumbo nucifera [Reaction:R-ATH-1120370] 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase - Arabidopsis thaliana
output	[SimpleEntity:R-ALL-174390] L-Met [cytosol] [SimpleEntity:R-ALL-4789073] tetrahydropteroyltri-L-glutamate [cytosol]
precedingEvent	[Reaction:R-OSA-1120657] cystathionine beta-lyase - Oryza sativa [Reaction:R-OSA-1121024] Adenosylhomocysteinase - Oryza sativa [BlackBoxEvent:R-OSA-4789101] plastid to cytosol transport - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120370
summation	[Summation:4789104] L-homocysteine is converted to L-methionine by enzymatic act...

Referrals

(hasEvent)	[Pathway:R-OSA-1119501] S-adenosyl-L-methionine cycle - Oryza sativa [Pathway:R-OSA-1119400] Methionine biosynthesis II - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1121647] Methionine adenosyltransferase - Oryza sativa