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Glutathione-disulfide reductase

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catalystActivity	[CatalystActivity:1118382] glutathione-disulfide reductase (NADPH) activity of Glutathione-disulfide reductase. [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference	[DatabaseIdentifier:26905] EC:1.8.1.7 [DatabaseIdentifier:1142574] RiceCyc:GLUTATHIONE-REDUCT-NADPH-RXN
dbId	1120206
displayName	Glutathione-disulfide reductase
eventOf	[Pathway:R-OSA-1119298] Glutathione redox reactions II - Oryza sativa [Pathway:R-OSA-1119437] Glutathione redox reactions I - Oryza sativa
followingEvent	[Reaction:R-OSA-1120227] Phospholipid-hydroperoxide glutathione peroxidase - Oryza sativa [Reaction:R-OSA-1121374] glutathione peroxidase - Oryza sativa [Reaction:R-OSA-1120419] Protein-disulfide reductase (glutathione) - Oryza sativa
input	[SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
modified	[InstanceEdit:11540225] Elser, Justin, 2025-03-27
name	Glutathione-disulfide reductase Glutathione reductase (NADPH) NADPH-glutathione reductase GSH reductase GSSG reductase NADPH-GSSG reductase Glutathione S-reductase NADPH:oxidized-glutathione oxidoreductase Glutathione reductase biochemicalReaction78135
orthologousEvent	[Reaction:R-VVN-1120206] Glutathione-disulfide reductase - Vitis vinifera [Reaction:R-AHY-1120206] Glutathione-disulfide reductase - Arachis hypogaea [Reaction:R-ETE-1120206] Glutathione-disulfide reductase - Eragrostis tef [Reaction:R-BDI-1120206] Glutathione-disulfide reductase - Brachypodium distachyon [Reaction:R-FVE-1120206] Glutathione-disulfide reductase - Fragaria vesca [Reaction:R-ADU-1120206] Glutathione-disulfide reductase - Arachis duranensis [Reaction:R-AOF-1120206] Glutathione-disulfide reductase - Asparagus officinalis [Reaction:R-OGL-1120206] Glutathione-disulfide reductase - Oryza glaberrima [Reaction:R-VAN-1120206] Glutathione-disulfide reductase - Vigna angularis [Reaction:R-LPE-1120206] Glutathione-disulfide reductase - Leersia perrieri [Reaction:R-CCL-1120206] Glutathione-disulfide reductase - Citrus clementina [Reaction:R-PHA-1120206] Glutathione-disulfide reductase - Panicum hallii ("FIL2") [Reaction:R-TTI-1120206] Glutathione-disulfide reductase - Triticum timopheevii subsp. timopheevii [Reaction:R-CBA-1120206] Glutathione-disulfide reductase - Chara braunii [Reaction:R-OSI-1120206] Glutathione-disulfide reductase - Oryza sativa Indica Group [Reaction:R-RCH-1120206] Glutathione-disulfide reductase - Rosa chinensis [Reaction:R-OMI-1120206] Glutathione-disulfide reductase - Oryza minuta [Reaction:R-SMO-1120206] Glutathione-disulfide reductase - Selaginella moellendorffii [Reaction:R-SSP-1120206] Glutathione-disulfide reductase - Saccharum spontaneum [Reaction:R-VRA-1120206] Glutathione-disulfide reductase - Vigna radiata [Reaction:R-JCU-1120206] Glutathione-disulfide reductase - Jatropha curcas [Reaction:R-MDO-1120206] Glutathione-disulfide reductase - Malus domestica [Reaction:R-CCA-1120206] Glutathione-disulfide reductase - Cajanus cajan [Reaction:R-AUM-1120206] Glutathione-disulfide reductase - Aegilops umbellulata [Reaction:R-OGR-1120206] Glutathione-disulfide reductase - Oryza meyeriana var. granulata [Reaction:R-CST-1120206] Glutathione-disulfide reductase - Camelina sativa [Reaction:R-CRE-1120206] Glutathione-disulfide reductase - Chlamydomonas reinhardtii [Reaction:R-LST-1120206] Glutathione-disulfide reductase - Lathyrus sativus [Reaction:R-CME-1120206] Glutathione-disulfide reductase - Cyanidioschyzon merolae [Reaction:R-MPO-1120206] Glutathione-disulfide reductase - Marchantia polymorpha [Reaction:R-GSO-1120206] Glutathione-disulfide reductase - Glycine soja [Reaction:R-ATH-1120206] Glutathione-disulfide reductase - Arabidopsis thaliana [Reaction:R-OBA-1120206] Glutathione-disulfide reductase - Oryza barthii [Reaction:R-OOF-1120206] Glutathione-disulfide reductase - Oryza officinalis [Reaction:R-JRE-1120206] Glutathione-disulfide reductase - Juglans regia [Reaction:R-CCI-1120206] Glutathione-disulfide reductase - Corymbia citriodora [Reaction:R-TSP-1120206] Glutathione-disulfide reductase - Triticum spelta subsp. spelta [Reaction:R-FEX-1120206] Glutathione-disulfide reductase - Fraxinus excelsior (European ash) [Reaction:R-EGR-1120206] Glutathione-disulfide reductase - Eucalyptus grandis [Reaction:R-OBR-1120206] Glutathione-disulfide reductase - Oryza brachyantha [Reaction:R-TPR-1120206] Glutathione-disulfide reductase - Trifolium pratense [Reaction:R-ZJA-1120206] Glutathione-disulfide reductase - Zoysia japonica [Reaction:R-HAN-1120206] Glutathione-disulfide reductase - Helianthus annuus [Reaction:R-CSK-1120206] Glutathione-disulfide reductase - Cannabis sativa subsp. indica [Reaction:R-ONI-1120206] Glutathione-disulfide reductase - Oryza nivara [Reaction:R-OAU-1120206] Glutathione-disulfide reductase - Oryza australiensis [Reaction:R-SHI-1120206] Glutathione-disulfide reductase - Salvia hispanica [Reaction:R-SLY-1120206] Glutathione-disulfide reductase - Solanum lycopersicum [Reaction:R-OLU-1120206] Glutathione-disulfide reductase - Ostreococcus lucimarinus [Reaction:R-SIT-1120206] Glutathione-disulfide reductase - Setaria italica [Reaction:R-HLP-1120206] Glutathione-disulfide reductase - Humulus lupulus var. lupulus [Reaction:R-TUR-1120206] Glutathione-disulfide reductase - Triticum urartu [Reaction:R-ACO-1120206] Glutathione-disulfide reductase - Ananas comosus [Reaction:R-CQI-1120206] Glutathione-disulfide reductase - Chenopodium quinoa [Reaction:R-CLA-1120206] Glutathione-disulfide reductase - Citrullus lanatus [Reaction:R-VFA-1120206] Glutathione-disulfide reductase - Vicia faba var. faba [Reaction:R-OGU-1120206] Glutathione-disulfide reductase - Oryza glumaepatula [Reaction:R-PED-1120206] Glutathione-disulfide reductase - Phyllostachys edulis [Reaction:R-SIN-1120206] Glutathione-disulfide reductase - Sesamum indicum [Reaction:R-DCA-1120206] Glutathione-disulfide reductase - Daucus carota [Reaction:R-OPU-1120206] Glutathione-disulfide reductase - Oryza punctata [Reaction:R-BNA-1120206] Glutathione-disulfide reductase - Brassica napus [Reaction:R-SBI-1120206] Glutathione-disulfide reductase - Sorghum bicolor [Reaction:R-ITR-1120206] Glutathione-disulfide reductase - Ipomoea triloba [Reaction:R-GSU-1120206] Glutathione-disulfide reductase - Galdieria sulphuraria [Reaction:R-ATR-1120206] Glutathione-disulfide reductase - Amborella trichopoda [Reaction:R-ALY-1120206] Glutathione-disulfide reductase - Arabidopsis lyrata [Reaction:R-CAN-1120206] Glutathione-disulfide reductase - Capsicum annuum [Reaction:R-PPE-1120206] Glutathione-disulfide reductase - Prunus persica [Reaction:R-CSA-1120206] Glutathione-disulfide reductase - Cucumis sativus [Reaction:R-SVI-1120206] Glutathione-disulfide reductase - Setaria viridis [Reaction:R-ZMA-1120206] Glutathione-disulfide reductase - Zea mays [Reaction:R-GMA-1120206] Glutathione-disulfide reductase - Glycine max [Reaction:R-TCA-1120206] Glutathione-disulfide reductase - Theobroma cacao [Reaction:R-CRU-1120206] Glutathione-disulfide reductase - Capsella rubella [Reaction:R-ORU-1120206] Glutathione-disulfide reductase - Oryza rufipogon [Reaction:R-OLO-1120206] Glutathione-disulfide reductase - Oryza longistaminata [Reaction:R-CCR-1120206] Glutathione-disulfide reductase - Chondrus crispus [Reaction:R-VUN-1120206] Glutathione-disulfide reductase - Vigna unguiculata [Reaction:R-FCR-1120206] Glutathione-disulfide reductase - Ficus carica [Reaction:R-CAR-1120206] Glutathione-disulfide reductase - Cicer arietinum [Reaction:R-ATA-1120206] Glutathione-disulfide reductase - Aegilops tauschii [Reaction:R-ECU-1120206] Glutathione-disulfide reductase - Eragrostis curvula [Reaction:R-MTR-1120206] Glutathione-disulfide reductase - Medicago truncatula [Reaction:R-CSC-1120206] Glutathione-disulfide reductase - Cannabis sativa [Reaction:R-OES-1120206] Glutathione-disulfide reductase - Olea europaea var. sylvestris [Reaction:R-NCO-1120206] Glutathione-disulfide reductase - Nymphaea colorata [Reaction:R-OME-1120206] Glutathione-disulfide reductase - Oryza meridionalis [Reaction:R-LAN-1120206] Glutathione-disulfide reductase - Lupinus angustifolius [Reaction:R-ZMY-1120206] Glutathione-disulfide reductase - Zea mays ver5 [Reaction:R-STU-1120206] Glutathione-disulfide reductase - Solanum tuberosum [Reaction:R-HVU-1120206] Glutathione-disulfide reductase - Hordeum vulgare [Reaction:R-ASA-1120206] Glutathione-disulfide reductase - Avena sativa [Reaction:R-PTI-1120206] Glutathione-disulfide reductase - Populus trichocarpa [Reaction:R-BRA-1120206] Glutathione-disulfide reductase - Brassica rapa [Reaction:R-TAE-1120206] Glutathione-disulfide reductase - Triticum aestivum [Reaction:R-ACH-1120206] Glutathione-disulfide reductase - Actinidia chinensis [Reaction:R-PTA-1120206] Glutathione-disulfide reductase - Pinus taeda [Reaction:R-LPR-1120206] Glutathione-disulfide reductase - Lolium perenne [Reaction:R-PVE-1120206] Glutathione-disulfide reductase - Pistacia vera [Reaction:R-PDA-1120206] Glutathione-disulfide reductase - Phoenix dactylifera [Reaction:R-DRO-1120206] Glutathione-disulfide reductase - Dioscorea rotundata [Reaction:R-CML-1120206] Glutathione-disulfide reductase - Cucumis melo [Reaction:R-PPA-1120206] Glutathione-disulfide reductase - Physcomitrella patens [Reaction:R-NNU-1120206] Glutathione-disulfide reductase - Nelumbo nucifera [Reaction:R-TDI-1120206] Glutathione-disulfide reductase - Triticum dicoccoides [Reaction:R-PHH-1120206] Glutathione-disulfide reductase - Panicum hallii var. hallii ("HAL2") [Reaction:R-QSU-1120206] Glutathione-disulfide reductase - Quercus suber [Reaction:R-CCD-1120206] Glutathione-disulfide reductase - Cynara cardunculus var. scolymus [Reaction:R-DEX-1120206] Glutathione-disulfide reductase - Digitaria exilis [Reaction:R-TTU-1120206] Glutathione-disulfide reductase - Triticum turgidum [Reaction:R-ECG-1120206] Glutathione-disulfide reductase - Echinochloa crus-galli [Reaction:R-NAT-1120206] Glutathione-disulfide reductase - Nicotiana attenuata [Reaction:R-MGU-1120206] Glutathione-disulfide reductase - Erythranthe guttata [Reaction:R-AHA-1120206] Glutathione-disulfide reductase - Arabidopsis halleri [Reaction:R-CCN-1120206] Glutathione-disulfide reductase - Coffea canephora [Reaction:R-MAC-1120206] Glutathione-disulfide reductase - Musa acuminata [Reaction:R-BJU-1120206] Glutathione-disulfide reductase - Brassica juncea [Reaction:R-PAB-1120206] Glutathione-disulfide reductase - Picea abies [Reaction:R-CSI-1120206] Glutathione-disulfide reductase - Citrus sinensis [Reaction:R-AIP-1120206] Glutathione-disulfide reductase - Arachis ipaensis [Reaction:R-HLH-1120206] Glutathione-disulfide reductase - Humulus lupulus [Reaction:R-MES-1120206] Glutathione-disulfide reductase - Manihot esculenta [Reaction:R-CCP-1120206] Glutathione-disulfide reductase - Corchorus capsularis [Reaction:R-PAV-1120206] Glutathione-disulfide reductase - Prunus avium [Reaction:R-BVU-1120206] Glutathione-disulfide reductase - Beta vulgaris [Reaction:R-BOL-1120206] Glutathione-disulfide reductase - Brassica oleracea [Reaction:R-OEU-1120206] Glutathione-disulfide reductase - Olea europaea [Reaction:R-GRA-1120206] Glutathione-disulfide reductase - Gossypium raimondii [Reaction:R-COL-1120206] Glutathione-disulfide reductase - Corchorus olitorius [Reaction:R-PSO-1120206] Glutathione-disulfide reductase - Papaver somniferum [Reaction:R-LSA-1120206] Glutathione-disulfide reductase - Lactuca sativa [Reaction:R-PVU-1120206] Glutathione-disulfide reductase - Phaseolus vulgaris [Reaction:R-SCR-1120206] Glutathione-disulfide reductase - Secale cereale [Reaction:R-PSA-1120206] Glutathione-disulfide reductase - Pisum sativum [Reaction:R-QLO-1120206] Glutathione-disulfide reductase - Quercus lobata
output	2 × [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-OSA-1120419] Protein-disulfide reductase (glutathione) - Oryza sativa [Reaction:R-OSA-1120227] Phospholipid-hydroperoxide glutathione peroxidase - Oryza sativa [Reaction:R-OSA-1121374] glutathione peroxidase - Oryza sativa
schemaClass	Reaction
species	[Species:186860] Oryza sativa
stId	R-OSA-1120206
summation	[Summation:3901345] Glutathione disulfide is converted into glutathione by enzym...

Referrals

(hasEvent)	[Pathway:R-OSA-1119437] Glutathione redox reactions I - Oryza sativa [Pathway:R-OSA-1119298] Glutathione redox reactions II - Oryza sativa
(precedingEvent)	[Reaction:R-OSA-1120419] Protein-disulfide reductase (glutathione) - Oryza sativa [Reaction:R-OSA-1120227] Phospholipid-hydroperoxide glutathione peroxidase - Oryza sativa [Reaction:R-OSA-1121374] glutathione peroxidase - Oryza sativa