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Association of RPA proteins with Pre-RC at origin

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compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10728358] Elser, Justin, 2025-03-25
dbId	10737766
displayName	Association of RPA proteins with Pre-RC at origin
eventOf	[Pathway:R-MES-9645850] Activation of pre-replication complex - Manihot esculenta
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-MES-9645813] Binding of DNA polymerase alpha:primase at origin - Manihot esculenta [Reaction:R-MES-9645988] Binding of DNA polymerase epsilon at origin - Manihot esculenta
inferredFrom	[Reaction:R-OSA-9645845] Association of RPA proteins with Pre-RC at origin - Oryza sativa
input	[Complex:R-MES-9645863] MCM10:active pre-RC:CDC45:TOPBP1 [nucleoplasm] [Complex:R-MES-9646019] RPA-B [nucleoplasm] [Complex:R-MES-9646041] RPA-C [nucleoplasm]
isInDisease	false
isInferred	true
name	Association of RPA proteins with Pre-RC at origin
output	[Complex:R-MES-9646014] MCM10:active pre-RC:CDC45:TOPBP1:RPA-BC [nucleoplasm]
precedingEvent	[Reaction:R-MES-9645867] Recruitment of CDC45 - Manihot esculenta
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9030186] Manihot esculenta
stId	R-MES-9645845
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-MES-9645850] Activation of pre-replication complex - Manihot esculenta
(precedingEvent)	[Reaction:R-MES-9645813] Binding of DNA polymerase alpha:primase at origin - Manihot esculenta [Reaction:R-MES-9645988] Binding of DNA polymerase epsilon at origin - Manihot esculenta
(inferredTo)	[Reaction:R-OSA-9645845] Association of RPA proteins with Pre-RC at origin - Oryza sativa

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