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RBOHs generate superoxide from oxygen during respiration in the mitochondria

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catalystActivity	[CatalystActivity:10736554] superoxide-generating NAD(P)H oxidase activity of RBOH / NADPH oxidases [mitochondrion]
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane [Compartment:5462] mitochondrion
created	[InstanceEdit:10728358] Elser, Justin, 2025-03-25
dbId	10736556
displayName	RBOHs generate superoxide from oxygen during respiration in the mitochondria
eventOf	[Pathway:R-MES-9607185] Generation of superoxide radicals - Manihot esculenta
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-MES-9607107] Superoxide dismutase mt - Manihot esculenta
inferredFrom	[Reaction:R-OSA-9607109] RBOHs generate superoxide from oxygen during respiration in the mitochondria - Oryza sativa
input	[SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
name	RBOHs generate superoxide from oxygen during respiration in the mitochondria
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-3299683] O2.- [mitochondrial matrix]
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9030186] Manihot esculenta
stId	R-MES-9607109
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(precedingEvent)	[Reaction:R-MES-9607107] Superoxide dismutase mt - Manihot esculenta
(hasEvent)	[Pathway:R-MES-9607185] Generation of superoxide radicals - Manihot esculenta
(inferredTo)	[Reaction:R-OSA-9607109] RBOHs generate superoxide from oxygen during respiration in the mitochondria - Oryza sativa

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