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Conversion of ISB-CoA to MACR-CoA

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catalystActivity	[CatalystActivity:10724695] 3-methylbutanoyl-CoA dehydrogenase activity of Isovaleryl-CoA dehydrogenase [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10714991] Elser, Justin, 2025-03-25
dbId	10724697
displayName	Conversion of ISB-CoA to MACR-CoA
eventOf	[Pathway:R-LAN-1119479] Valine degradation - Lupinus angustifolius
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-LAN-9611868] Conversion of MACR-CoA to 3-hydroxy-isobutyryl-CoA - Lupinus angustifolius
inferredFrom	[Reaction:R-OSA-9611898] Conversion of ISB-CoA to MACR-CoA - Oryza sativa
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [SimpleEntity:R-ALL-70851] ISB-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
name	Conversion of ISB-CoA to MACR-CoA
output	[SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix] [SimpleEntity:R-ALL-70858] MACR-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-LAN-9611876] Conversion of KIV to ISB-CoA - Lupinus angustifolius
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9030174] Lupinus angustifolius
stId	R-LAN-9611898
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-LAN-1119479] Valine degradation - Lupinus angustifolius
(precedingEvent)	[Reaction:R-LAN-9611868] Conversion of MACR-CoA to 3-hydroxy-isobutyryl-CoA - Lupinus angustifolius
(inferredTo)	[Reaction:R-OSA-9611898] Conversion of ISB-CoA to MACR-CoA - Oryza sativa