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malate + NAD+ <=> oxaloacetate + NADH + H+

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catalystActivity	[CatalystActivity:10127666] L-malate dehydrogenase (NAD+) activity of MDH [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10122017] Elser, Justin, 2025-03-24
dbId	10127668
displayName	malate + NAD+ <=> oxaloacetate + NADH + H+
eventOf	[Pathway:R-HLP-1119533] TCA cycle (plant) - Humulus lupulus var. lupulus
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-HLP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Humulus lupulus var. lupulus
inferredFrom	[Reaction:R-OSA-1120787] malate + NAD+ <=> oxaloacetate + NADH + H+ - Oryza sativa
input	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	malate + NAD+ <=> oxaloacetate + NADH + H+ Malate dehydrogenase
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
precedingEvent	[Reaction:R-HLP-1121548] fumarate + H2O <=> malate - Humulus lupulus var. lupulus
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9659299] Humulus lupulus var. lupulus
stId	R-HLP-1120787
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-HLP-1119533] TCA cycle (plant) - Humulus lupulus var. lupulus
(precedingEvent)	[Reaction:R-HLP-1120092] oxaloacetate + acetyl-CoA + H2O => citrate + CoA-SH - Humulus lupulus var. lupulus
(inferredTo)	[Reaction:R-OSA-1120787] malate + NAD+ <=> oxaloacetate + NADH + H+ - Oryza sativa