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a folylpolyglutamate(n)+L-glutamate+ATP->a folylpolyglutamate(n+1)+phosphate+ADP

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catalystActivity	[CatalystActivity:11440999] tetrahydrofolylpolyglutamate synthase activity of Tetrahydrofolate synthase. [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11440306] Elser, Justin, 2025-03-26
dbId	11441001
displayName	a folylpolyglutamate(n)+L-glutamate+ATP->a folylpolyglutamate(n+1)+phosphate+ADP
eventOf	[Pathway:R-FEX-1119484] Folate polyglutamylation II - Fraxinus excelsior (European ash)
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-FEX-1121206] Folatepolyglutamate(n) - Fraxinus excelsior (European ash)
inferredFrom	[Reaction:R-OSA-1119838] a folylpolyglutamate(n)+L-glutamate+ATP->a folylpolyglutamate(n+1)+phosphate+ADP - Oryza sativa
input	[SimpleEntity:R-ALL-1132041] a folylpolyglutamate(n) [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	true
name	a folylpolyglutamate(n)+L-glutamate+ATP->a folylpolyglutamate(n+1)+phosphate+ADP RXN-3742 biochemicalReaction6747
output	[SimpleEntity:R-ALL-1131932] a folylpolyglutamate(n+1) [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-FEX-1121206] Folatepolyglutamate(n) - Fraxinus excelsior (European ash)
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9933481] Fraxinus excelsior (European ash)
stId	R-FEX-1119838
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-FEX-1119484] Folate polyglutamylation II - Fraxinus excelsior (European ash)
(precedingEvent)	[Reaction:R-FEX-1121206] Folatepolyglutamate(n) - Fraxinus excelsior (European ash)
(inferredTo)	[Reaction:R-OSA-1119838] a folylpolyglutamate(n)+L-glutamate+ATP->a folylpolyglutamate(n+1)+phosphate+ADP - Oryza sativa