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Association of RPA proteins with Pre-RC at origin

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compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10307738] Elser, Justin, 2025-03-24
dbId	10316612
displayName	Association of RPA proteins with Pre-RC at origin
eventOf	[Pathway:R-EGR-9645850] Activation of pre-replication complex - Eucalyptus grandis
evidenceType	[EvidenceType:9939645] inferred by electronic annotation
followingEvent	[Reaction:R-EGR-9645813] Binding of DNA polymerase alpha:primase at origin - Eucalyptus grandis [Reaction:R-EGR-9645988] Binding of DNA polymerase epsilon at origin - Eucalyptus grandis
inferredFrom	[Reaction:R-OSA-9645845] Association of RPA proteins with Pre-RC at origin - Oryza sativa
input	[Complex:R-EGR-9645863] MCM10:active pre-RC:CDC45:TOPBP1 [nucleoplasm] [Complex:R-EGR-9646019] RPA-B [nucleoplasm] [Complex:R-EGR-9646041] RPA-C [nucleoplasm]
isInDisease	false
isInferred	true
name	Association of RPA proteins with Pre-RC at origin
output	[Complex:R-EGR-9646014] MCM10:active pre-RC:CDC45:TOPBP1:RPA-BC [nucleoplasm]
precedingEvent	[Reaction:R-EGR-9645867] Recruitment of CDC45 - Eucalyptus grandis
releaseDate	2025-02-15
schemaClass	Reaction
species	[Species:9029945] Eucalyptus grandis
stId	R-EGR-9645845
summation	[Summation:9939644] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mappings from Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 1% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome.

Referrals

(hasEvent)	[Pathway:R-EGR-9645850] Activation of pre-replication complex - Eucalyptus grandis
(precedingEvent)	[Reaction:R-EGR-9645813] Binding of DNA polymerase alpha:primase at origin - Eucalyptus grandis [Reaction:R-EGR-9645988] Binding of DNA polymerase epsilon at origin - Eucalyptus grandis
(inferredTo)	[Reaction:R-OSA-9645845] Association of RPA proteins with Pre-RC at origin - Oryza sativa

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