UniProt:Q6K431 TRX1

chain
  • chain:1-1022
checksum 121B74C4998D773A
comment
  • FUNCTION Possesses histone H3 methyltransferase activity in vitro (PubMed:24420930). Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which negatively regulates its transcriptional activation activity (By similarity). Involved in the regulation of flowering time and floral induction under long day (LD) conditions. Acts as an activator of flowering under LD conditions. May function through binding to EHD3, a repressor of GHD7 (PubMed:24420930).CATALYTIC ACTIVITY L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)SUBUNIT Interacts with EHD3.SUBCELLULAR LOCATION Expressed in leaf blades and panicles.DISRUPTION PHENOTYPE Late-flowering phenotype under long day (LD) conditions.SIMILARITY Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
created [InstanceEdit:9927753] Gupta, Parul, 2024-11-08
databaseName UniProt
dbId 9927768
description
  • recommendedName: fullName evidence="14"Histone-lysine N-methyltransferase TRX1 shortName evidence="13"OsTrx1 ecNumber evidence="11"2.1.1.364 alternativeName: fullName evidence="14"Protein SET DOMAIN GROUP 723 alternativeName: fullName evidence="14"SET family protein 33 shortName evidence="12"OsSET33
displayName UniProt:Q6K431 TRX1
geneName
  • TRX1
  • SDG723
  • SET
  • Os09g0134500
  • LOC_Os09g04890
  • P0406E03.49-1
  • P0406E03.49-2
identifier Q6K431
isSequenceChanged false
keyword
  • Alternative splicing
  • Chromatin regulator
  • Flowering
  • Metal-binding
  • Methyltransferase
  • Nucleus
  • Reference proteome
  • S-adenosyl-L-methionine
  • Transferase
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • TRX1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRX1_ORYSJ
  • Q6K430
sequenceLength 1022
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6K431