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OSMYB61 , a transcriptional factor that regulates cellulose synthesis, is directly regulated by a known NUE regulator GROWTH-REGULATING FACTOR4 (GRF4), which coordinates cellulosic biomass production and N utilization. The variation at MYB61 has been selected during indica and japonica domestication(PMID: 33060584). The indica allele of MYB61 displays robust transcription resulting in higher NUE and increased grain yield at reduced N supply than that of japonica (PMID: 33060584). OSMYB61 transcription factor is upregulated in response to submergence during seed germination and coleoptile growth.
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