UniProt:A3C4S4 GME-1

chain
  • chain:1-378
checksum 4BAE83BB932C321A
comment
  • FUNCTION Catalyzes a reversible epimerization of GDP-D-mannose that precedes the committed step in the biosynthesis of vitamin C (L-ascorbate), resulting in the hydrolysis of the highly energetic glycosyl-pyrophosphoryl linkage. Able to catalyze 2 distinct epimerization reactions and can release both GDP-L-galactose and GDP-L-gulose from GDP-mannose.CATALYTIC ACTIVITY GDP-alpha-D-mannose = GDP-beta-L-guloseCATALYTIC ACTIVITY GDP-beta-L-gulose = GDP-beta-L-galactoseCOFACTOR Strongly activated by NAD. Activated by NADP. Slightly activated by NADH and NADPH. Inhibited by GDP.BIOPHYSICOCHEMICAL PROPERTIES The catalytic efficiency increases by 2-fold in the presence of NAD(+).PATHWAY Cofactor biosynthesis; L-ascorbate biosynthesis via GDP-alpha-D-mannose pathway; L-ascorbate from GDP-alpha-D-mannose: step 1/5.SUBUNIT Homodimer.SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family.
created [InstanceEdit:9682524] Gupta, Parul, 2020-04-08
databaseName UniProt
dbId 9682499
description
  • recommendedName: GDP-mannose 3,5-epimerase 1 shortName: GDP-Man 3,5-epimerase 1 ecNumber evidence="3"5.1.3.18 alternativeName: OsGME-1
displayName UniProt:A3C4S4 GME-1
geneName
  • GME-1
  • Os10g0417600
  • LOC_Os10g28200
  • OsJ_030296
  • OSJNBa0061K21.15
identifier A3C4S4
isSequenceChanged false
keyword
  • Ascorbate biosynthesis
  • Isomerase
  • NAD
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • GME-1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GME1_ORYSJ
  • B7EX80
  • Q0IXP2
  • Q0R4F5
  • Q109P5
  • Q338B5
  • Q5W7P1
  • Q8S862
sequenceLength 378
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/A3C4S4