UniProt:Q9LRE6 POLD1

chain
  • chain:1-1105
checksum C309447C049D42C1
comment
  • FUNCTION This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.CATALYTIC ACTIVITY DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphateCOFACTOR Binds 1 [4Fe-4S] cluster.SUBUNIT Heterodimer with subunits of 125 kDa and 50 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity (By similarity).SUBCELLULAR LOCATION The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.MISCELLANEOUS In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.SIMILARITY Belongs to the DNA polymerase type-B family.
created [InstanceEdit:9675795] Gupta, Parul, 2020-02-05
databaseName UniProt
dbId 9675792
description
  • recommendedName: DNA polymerase delta catalytic subunit ecNumber: 2.7.7.7
displayName UniProt:Q9LRE6 POLD1
geneName
  • POLD1
  • Os11g0186400
  • LOC_Os11g08330
identifier Q9LRE6
isSequenceChanged false
keyword
  • 4Fe-4S
  • DNA replication
  • DNA-binding
  • DNA-directed DNA polymerase
  • Exonuclease
  • Hydrolase
  • Iron
  • Iron-sulfur
  • Metal-binding
  • Nuclease
  • Nucleotidyltransferase
  • Nucleus
  • Reference proteome
  • Transferase
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • POLD1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DPOD1_ORYSJ
  • A0A0N7KSJ4
  • Q2R9L5
  • Q53NH0
  • Q53P50
sequenceLength 1105
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q9LRE6