UniProt:Q10N20 MPK5

chain
  • chain:1-369
checksum 417D81732635F2D3
comment
  • FUNCTION Involved in disease resistance and abiotic stress tolerance signaling pathways. Acts as a positive regulator of drought, salt and cold tolerance. Negatively modulates pathogenesis-related (PR) gene expression and broad-spectrum disease resistance (PubMed:12615946). Functions downstream of CPK18 in a signaling pathway that represses defense gene expression and negatively regulates resistance to rice blast fungus. Phosphorylated by CPK18 at Thr-14 and Thr-32 and activated independently of MAP kinase kinase (MKK) phosphorylation (PubMed:25035404).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by threonine and tyrosine phosphorylation (By similarity). Activated in response to low temperature (12 degrees Celsius) treatment (PubMed:12177502, PubMed:12615946). Activated by phosphorylation at Thr-14 and Thr-32 by CPK18 (PubMed:25035404).SUBUNIT Interacts with MKK1 (PubMed:12177502). Interacts with CPK18 (PubMed:25035404).SUBCELLULAR LOCATION Expressed in roots, stems and panicles, and at lower levels in leaves.INDUCTION By benzothiadiazole (BTH), dichloroisonicotinic acid, probenazole, jasmonic acid, wounding and infection with P.syringae and M.grisea, by stresses, hormones, heavy metals, high/low temperature, UV-C and phosphatase inhibitors.DOMAIN The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM Dually phosphorylated at Thr-194 and Tyr-196, which activates the enzyme (By similarity). Autophosphorylated. Phosphorylated by CPK18 at Thr-14 and Thr-32, which activates the enzyme (PubMed:25035404).MISCELLANEOUS Does not possess kinase activity.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:9675413] Gupta, Parul, 2020-02-04
databaseName UniProt
dbId 9675432
description
  • recommendedName: Mitogen-activated protein kinase 5 shortName: MAP kinase 5 ecNumber: 2.7.11.24 alternativeName: Benzothiadiazole-induced MAP kinase 1 alternativeName: MAP kinase 2 alternativeName: Multiple stress-responsive MAP kinase 2 alternativeName: OsBIMK1 alternativeName: OsMAP1 alternativeName: OsMAPK2 alternativeName: OsMAPK5 alternativeName: OsMPK3 alternativeName: OsMSRMK2
displayName UniProt:Q10N20 MPK5
geneName
  • MPK5
  • BIMK1
  • MAPK2
  • MAPK5
  • MPK3
  • MSRMK2
  • Os03g0285800
  • LOC_Os03g17700
  • OsJ_10412
  • OSJNBa0013D02.9
identifier Q10N20
isSequenceChanged false
keyword
  • Alternative splicing
  • ATP-binding
  • Cytoplasm
  • Kinase
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Plant defense
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • MPK5
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MPK5_ORYSJ
  • B7EDC7
  • Q7FNE2
  • Q8GZZ3
  • Q8S3T6
  • Q9AXF2
  • Q9FQM3
  • Q9FSE6
sequenceLength 369
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q10N20