UniProt:Q5NAI7 PAO1

chain
  • chain:1-512
checksum B73C87D3C909927B
comment
  • FUNCTION Flavoenzyme involved in polyamine back-conversion (PubMed:24105034). Catalyzes the oxidation of the secondary amino group of polyamines, such as spermine and its acetyl derivatives (PubMed:24105034). Substrate preference is thermospermine > spermine > norspermine > N(1)-acetylspermine (PubMed:24105034). No activity detected when putrescine or spermidine are used as substrates (PubMed:24105034). Plays an important role in the regulation of polyamine intracellular concentration (Probable).CATALYTIC ACTIVITY spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2CATALYTIC ACTIVITY N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2CATALYTIC ACTIVITY norspermine + O2 + H2O = norspermidine + 3-aminopropanal + H2O2CATALYTIC ACTIVITY thermospermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2COFACTOR Binds 1 FAD per subunit.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6.0 with thermospermine as substrate (PubMed:24105034). Optimum pH is 8.5 with spermine as substrate (PubMed:24105034).PATHWAY Amine and polyamine degradation; spermine degradation.SUBCELLULAR LOCATION Induced in roots by exogenous treatment with spermine and thermospermine.SIMILARITY Belongs to the flavin monoamine oxidase family.
created [InstanceEdit:9658642] Gupta, Parul, 2019-08-16
databaseName UniProt
dbId 9658654
description
  • recommendedName: fullName evidence="4"Polyamine oxidase 1 shortName evidence="4"OsPAO1 ecNumber evidence="3"1.5.3.- alternativeName: fullName evidence="5"OsAO4
displayName UniProt:Q5NAI7 PAO1
geneName
  • PAO1
  • Os01g0710200
  • LOC_Os01g51320
  • OsJ_03212
  • P0456F08.19
identifier Q5NAI7
isSequenceChanged false
keyword
  • Cytoplasm
  • FAD
  • Flavoprotein
  • Oxidoreductase
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • PAO1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PAO1_ORYSJ
sequenceLength 512
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q5NAI7