Activation of pre-RC complex is also known as pre-initiation...

created [InstanceEdit:9646027] Gupta, Parul, 2019-05-17
dbId 9646049
displayName Activation of pre-RC complex is also known as pre-initiation...
modified [InstanceEdit:9646192] Gupta, Parul, 2019-05-17
schemaClass Summation
text Activation of pre-RC complex is also known as pre-initiation phase. Displacement of CDC6 from the origin, a step which is necessary for the final activation of MCM2-7. The next step is joining of MCM10 to the pre-RC complex. MCMs2-7, acting with MCM10 then recruit the DNA-polymerase-loading factor CDC45. Association of TOPBP1 with CDC45 is essential for
this step (Bryant, 2010). CDC45 is required for DNA polymerase alpha:primase complex loading (Shultz et al., 2007).