UniProt:P29620 CDKD-1

chain
  • chain:1-424
checksum 28606BE7120BB048
comment
  • FUNCTION CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)SUBUNIT Interacts with CYCH1-1.SUBCELLULAR LOCATION Expressed in actively dividing cells of roots, leaves and shoots. Expressed in the intercalary meristem and the elongation zone of internodes.DEVELOPMENTAL STAGE Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.INDUCTION By gibberellic acid (GA3) and submergence in the meristematic zone of internodes. Down-regulated by auxin.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
created [InstanceEdit:9640652] Gupta, Parul, 2019-04-03
databaseName UniProt
dbId 9640646
description
  • recommendedName: Cyclin-dependent kinase D-1 shortName: CDKD;1 ecNumber: 2.7.11.22 ecNumber: 2.7.11.23 alternativeName: CDC2+/CDC28-related protein kinase R2 alternativeName: CDK-activating kinase R2 shortName: CAK-R2
displayName UniProt:P29620 CDKD-1
geneName
  • CDKD-1
  • R2
  • Os05g0392300
  • LOC_Os05g32600
  • OJ1764_D01.12
identifier P29620
isSequenceChanged false
keyword
  • ATP-binding
  • Cell cycle
  • Cell division
  • Kinase
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • CDKD-1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CDKD1_ORYSJ
  • Q0DIF9
  • Q60ES0
sequenceLength 424
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/P29620