UniProt:Q5SMU7 ORC1

chain
  • chain:1-814
checksum F3E4B562A04F13B0
comment
  • FUNCTION Essential protein (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes (By similarity). Required for cell proliferation (PubMed:10996242).SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Binds unmodified and methylated histone H3 (By similarity).SUBCELLULAR LOCATION Expressed strongly in root tips and shoot apical meristem (SAM), and weakly in young leaves. Not detected in mature leaves.INDUCTION Reduced expression upon sucrose depletion-mediated cell proliferation arrest, and accumulates after sucrose treatment (PubMed:10996242, PubMed:15939553). Induced by gamma irradiation (PubMed:25124817).SIMILARITY Belongs to the ORC1 family.
created [InstanceEdit:9640652] Gupta, Parul, 2019-04-03
databaseName UniProt
dbId 9640624
description
  • recommendedName: fullName evidence="13"Origin of replication complex subunit 1 shortName evidence="13"OsORC1
displayName UniProt:Q5SMU7 ORC1
geneName
  • ORC1
  • Os06g0187000
  • LOC_Os06g08790
  • OsJ_20389
  • P0470C02.11
identifier Q5SMU7
isSequenceChanged false
keyword
  • Activator
  • ATP-binding
  • DNA replication
  • DNA-binding
  • Magnesium
  • Metal-binding
  • Nucleotide-binding
  • Nucleus
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9862192] Weiser, Joel, 2024-02-26
name
  • ORC1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ORC1_ORYSJ
  • Q0DDZ5
  • Q9MB44
sequenceLength 814
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q5SMU7