UniProt:Q0ILQ6 Os12g0631100

chain
  • chain:1-203
checksum 0C6FED6950BCA92F
comment
  • FUNCTION Plays an important role in intracellular trafficking of seed storage proteins to the protein storage vacuoles (PSVs) (PubMed:21105928). Participates in the transport of the proglutelins from the Golgi apparatus to the PSVs in endosperm (PubMed:21825104). Functions cooperatively with VPS9A to regulate post-Golgi dense vesicle-mediated transport of storage proteins to the type II protein bodies (PBII) protein storage vacuoles in developing endosperm (PubMed:23723154). Involved in the maintenance of the general structural organization of the endomembrane system in developing endosperm (PubMed:21105928, PubMed:21825104). Binds GTP in vitro (PubMed:21105928, PubMed:21825104, PubMed:23723154). Forms a quaternary complex with the two glutelin zipcode RNA-binding proteins RBP-L and RBP-P, and the membrane trafficking factor NSF (PubMed:32471860). This quaternay complex carries glutelin mRNAs for active transport on endosomes to the cortical endoplasmic reticulum membrane, and enables endosome-mediated glutelin mRNA transport in endosperm cells (PubMed:32471860).SUBUNIT Interacts with VPS9A (PubMed:23723154, PubMed:24488962). Interacts with NSF and RBP-L (PubMed:32471860).SUBCELLULAR LOCATION Highly expressed in roots (Ref.1). Expressed at low levels in shoots, flowers and grains (Ref.1).DEVELOPMENTAL STAGE Expression in developing seeds is low from 6 to 12 days after flowering (DAF), peaks at 12 DAF and is barely detected at 15 DAF.INDUCTION Induced by nitrogen and phosphorus starvation in roots.DISRUPTION PHENOTYPE Accumulation of proglutelins in seed endosperm (PubMed:21105928, PubMed:21825104). Mistargeting of dense vesicles (DVs) to the type II protein bodies (PBII) protein storage vacuoles and reduction of PBII size in endosperm. Formation of paramural bodies (PMBs) secretory vesicle-like structures charged with DVs in endosperm (PubMed:21105928, PubMed:21825104).SIMILARITY Belongs to the small GTPase superfamily. Rab family.
created [InstanceEdit:9626508] Gupta, Parul, 2018-10-27
databaseName UniProt
dbId 9626432
description
  • recommendedName: fullName evidence="11"Ras-related protein Rab5A shortName evidence="10"OsRab5A alternativeName: fullName evidence="9"Protein GLUTELIN PRECURSOR 4 alternativeName: fullName evidence="8"Protein GLUTELIN PRECURSOR ACCUMULATION 1
displayName UniProt:Q0ILQ6 Os12g0631100
geneName
  • Os12g0631100
  • LOC_Os12g43550
  • RAB5A
  • GLUP4
  • GPA1
identifier Q0ILQ6
isSequenceChanged false
keyword
  • Cell membrane
  • Golgi apparatus
  • GTP-binding
  • Lipoprotein
  • Membrane
  • Nucleotide-binding
  • Prenylation
  • Protein transport
  • Reference proteome
  • Transport
  • Vacuole
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • RAB5A
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB5A_ORYSJ
  • Q2QLR7
  • Q94IR3
  • Q9FEV1
sequenceLength 203
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q0ILQ6