Substrate specificity tests of Arabidopsis isovaleryl-CoA de...

created [InstanceEdit:9611891] Gupta, Parul, 2018-06-21
dbId 9611881
displayName Substrate specificity tests of Arabidopsis isovaleryl-CoA de...
modified [InstanceEdit:9611914] Gupta, Parul, 2018-06-21
schemaClass Summation
text Substrate specificity tests of Arabidopsis isovaleryl-CoA dehydrogenase (IVD) expressed in Escherichia coli showed a strong preference toward isovaleryl-CoA but also show considerable activity with isobutyryl-CoA. This strongly indicates that this enzyme has parallel activity towards isovaleryl-CoA and isobutyryl-CoA, thus involved in both pathways- leucine and valine catabolism. Such dual activity has not been observed with the animal IVD and may suggest a novel connection of the Leu and valine catabolism in plants.