UniProt:Q53M52 Os11g0247300

chain
  • chain:1-451
checksum 4EB46E096C684F0B
comment
  • FUNCTION Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.SUBCELLULAR LOCATION Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.PTM Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).SIMILARITY Belongs to the tubulin family.
created [InstanceEdit:9035635] Gupta, Parul, 2018-01-24
databaseName UniProt
dbId 9035724
description
  • recommendedName: Tubulin alpha-2 chain ecNumber evidence="2"3.6.5.-
displayName UniProt:Q53M52 Os11g0247300
geneName
  • Os11g0247300
  • LOC_Os11g14220
  • TUBA
identifier Q53M52
isSequenceChanged false
keyword
  • Acetylation
  • Cytoplasm
  • Cytoskeleton
  • GTP-binding
  • Hydrolase
  • Magnesium
  • Metal-binding
  • Microtubule
  • Nucleotide-binding
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • TUBA
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TBA2_ORYSJ
  • Q43606
sequenceLength 451
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q53M52