UniProt:Q6ZIK5 GRF4

chain
  • chain:1-394
checksum 3E71912F42AC1F6E
comment
  • FUNCTION Transcription activator that plays a role in the regulation of meristematic function in leaves, stems and inflorescences (PubMed:24532604). Transcription activator that plays a regulatory role in grain development (PubMed:26187814, PubMed:26936408, PubMed:27107174, PubMed:27250747, PubMed:27250749). Positively regulates grain size by promoting cell division and expansion, leading to increased grain length and width (PubMed:26187814, PubMed:26936408, PubMed:27107174, PubMed:27250747, PubMed:27250749). Positively regulates the expression of genes promoting cell proliferation (PubMed:26187814, PubMed:26936408). Activates the expression of expansin genes to promote cell expansion and grain size (PubMed:27250747). May promote grain size by activating brassinosteroid responses (PubMed:27250747). Component of a network formed by the microRNA396 (miRNA396), the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation (Probable). Component of the miRNA396c-GRF4-GIF1 regulatory module that plays an important role in grain size determination (Probable) (PubMed:27107174, PubMed:27250747, PubMed:27250749).ACTIVITY REGULATION Transactivation activity is repressed by GSK2.SUBUNIT Interacts with GIF1 (PubMed:27107174, PubMed:27250747, PubMed:27250749). Interacts with GSK2 (PubMed:27250747).SUBCELLULAR LOCATION Expressed in stems (PubMed:27107174). Expressed in panicles (PubMed:26187814, PubMed:27107174, PubMed:27250747, PubMed:27250749).INDUCTION The microRNA396c negatively regulates GRF4 at the transcriptional level.DOMAIN The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively (Probable). The C-terminal region downstream of the QLQ and WRC domains is necessary for transactivation activity (PubMed:26187814, PubMed:27107174, PubMed:27250747).POLYMORPHISM A two nucleotide mutation at the miRNA396c target site results in elevated transcript levels of GRF4, and the accumulation of GRF4 leads to enlarged cell size and increased cell number, which in turn results in enhanced grain weight and yield.MISCELLANEOUS Plants over-expressing GRF4 exhibit increased grain length, width and weight (PubMed:27107174). Plants silencing GRF4 exhibit dwarfism, delayed growth and inflorescence formation (PubMed:24532604).SIMILARITY Belongs to the GRF family.
created [InstanceEdit:9035635] Gupta, Parul, 2018-01-24
databaseName UniProt
dbId 9035719
description
  • recommendedName: fullName evidence="10"Growth-regulating factor 4 shortName evidence="10"OsGRF4 alternativeName: fullName evidence="13"Protein GRAIN LENGTH AND WIDTH 2 alternativeName: fullName evidence="11"Protein GRAIN SIZE ON CHROMOSOME 2 alternativeName: fullName evidence="12"Protein PANICLE TRAITS 2 alternativeName: fullName evidence="15"Transcription activator GRF4
displayName UniProt:Q6ZIK5 GRF4
geneName
  • GRF4
  • GL2
  • GLW2
  • GS2
  • PT2
  • Os02g0701300
  • LOC_Os02g47280
  • OJ1111_E07.19
  • OsJ_08054
identifier Q6ZIK5
isSequenceChanged false
keyword
  • Activator
  • Nucleus
  • Reference proteome
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
name
  • GRF4
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GRF4_ORYSJ
  • A0A0P0VNR1
  • B9F1Z2
  • Q70LH5
sequenceLength 394
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6ZIK5