UniProt:C0LT23 Os02g0656200

chain
  • chain:1-607
checksum D4014C87792F50A5
comment
  • FUNCTION Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Possesses activity on ceramide analog (C6 synthetic ceramide) in vitro. Ceramide is a critical sphingolipid metabolite that induces programmed cell death (PCD) in plants and ceramide-1-phosphate has a PCD suppressive effect. Thus, ceramide phosphorylation plays a role in the modulation of PCD and CERK activity is crucial for the maintenance of cell viability.CATALYTIC ACTIVITY an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)COFACTOR Optimum pH is 7.0 (at 40 degrees Celsius).TISSUE SPECIFICITY Highly expressed in leaves and at lower levels in stems.MISCELLANEOUS Overexpression of CERK in the Arabidopsis mutant acd5 restores wild-type phenotype.
created [InstanceEdit:9025502] Gupta, Parul, 2017-10-14
databaseName UniProt
dbId 9025444
description
  • recommendedName: Ceramide kinase shortName: OsCERK ecNumber: 2.7.1.138
displayName UniProt:C0LT23 Os02g0656200
geneName
  • Os02g0656200
  • CERK
  • LOC_Os02g43906/LOC_Os02g43912
  • OJ1003_B06.39
  • P0519E06.23
identifier C0LT23
isSequenceChanged false
keyword
  • ATP-binding
  • Calcium
  • Kinase
  • Magnesium
  • Metal-binding
  • Nucleotide-binding
  • Reference proteome
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • CERK
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CERK_ORYSJ
  • Q0DZ01
  • Q6H6H1
sequenceLength 607
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/C0LT23