UniProt:Q9FDY4 NPR1

chain
  • chain:1-582
checksum EBAED95839E6E76A
comment
  • FUNCTION Salicylic acid (SA)-binding substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Transcription cofactor that represses gene expression in the absence of salicylic acid (SA), when attached to negative cis-elements (W-box) with WRKY transcription factors, but stimulates gene expression upon activation by SA, when sumoylated and attached to positive cis-elements (as-1) with TGA transcription factors, thus confering immunity through a series of gene regulations ending in a significant increase in antimicrobial and defense genes expression (By similarity). Key positive factor of disease resistance. Plays an essential role in benzothiadiazole (BTH)-induced resistance to the blast fungus disease caused by Magnaporthe oryzae (PubMed:20924648). Involved in defense response against the bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo). Over-expression of NPR1/NH1 confers disease resistance to Xoo, but also enhances herbivore susceptibility (PubMed:17309686). Functions as a transcriptional coactivator of TGA2.1 and LG2 in vitro (PubMed:22353606). Involved in defense response against herbivore. Plants silencing NPR1/NH1 have increased herbivore-induced trypsin proteinase inhibitors and volatiles, which reduces the performance of the striped stem borer (SSB) Chilo suppressalis (PubMed:22694163).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Oligomer in an uninduced state; disulfide-linked. Forms activated monomer upon changes in cellular redox potential (PubMed:17309686). Interacts with TGA2.1, TGA2.2, TGA2.3, LG2, TGAL1 and TGAL4 (PubMed:24919709). Interacts with NRR, RH1, RH2 and RH3 (PubMed:22353606, PubMed:24919709).SUBCELLULAR LOCATION Accumulation as monomer in nucleus after induction by salicylic acid (SA) treatment or after pathogen infection.INDUCTION By mechanical wounding, treatment with jasmonic acid (JA), salicylic acid (SA) and benzothiadiazole (BTH), and in response to infestation by the rice striped stem borer Chilo suppressalis and rice leaf folder Cnaphalocrocis medinalis.DOMAIN The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes.SIMILARITY Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NPR1-like' subfamily.
created [InstanceEdit:6787965] Amarasinghe, Vindhya, 2015-07-18
databaseName UniProt
dbId 6787887
description
  • recommendedName: fullName evidence="14"BTB/POZ domain and ankyrin repeat-containing protein NPR1 shortName evidence="13"OsNPR1 alternativeName: fullName evidence="14"NPR1 homolog 1 shortName evidence="14"OsNH1
displayName UniProt:Q9FDY4 NPR1
geneName
  • NPR1
  • NH1
  • Os01g0194300
  • LOC_Os01g09800
  • P0001B06.13
  • P0671B11.44
identifier Q9FDY4
isSequenceChanged false
keyword
  • ANK repeat
  • Cytoplasm
  • Disulfide bond
  • Metal-binding
  • Nucleus
  • Plant defense
  • Reference proteome
  • Repeat
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • NPR1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NPR1_ORYSJ
  • Q7XBH3
sequenceLength 582
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q9FDY4