UniProt:Q7Y0Y8 Os06g0583400

chain
  • chain:1-518
checksum 2179EA9ED8D09EA4
comment
  • FUNCTION Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (Probable). Negatively regulates the expression of the NAC48/NAC6 gene that controls root growth in seedlings. Epigenetically represses the expression of NAC48/NAC6 by deacetylating 'Lys-9' (H3K9ac), 'Lys-14' (H3K14ac) and 'Lys-18' (H3K18ac) of histone H3, and 'Lys-5' (H4K5ac), 'Lys-12' (H4K12ac) and 'Lys-16' (H4K16ac) of histone H4 (PubMed:19453457). Functions in the regulation of gene expression in the whole genome (PubMed:12581311). Acts as a chromatin remodeling regulator to promote the formation of a repressive chromatin state. Functions with MODD via its interaction with TPR3, to down-regulates the histone acetylation level at BZIP46 target genes. BZIP46 is a positive regulator of abscisic acid (ABA) signaling and drought stress tolerance (PubMed:27468891).CATALYTIC ACTIVITY N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetateCOFACTOR Binds 1 zinc ion per subunit.SUBUNIT Interacts with TPR3.SUBCELLULAR LOCATION Expressed in roots and leaves.INDUCTION Down-regulated by drought and salt stresses.MISCELLANEOUS Plants over-expressing HDAC1 exhibit increased growth rate and altered plant architecture (PubMed:12581311). Plants silencing HDAC1 exhibit narrow leaves, reduced diameter of stems and reduced plant height (PubMed:19664599).SIMILARITY Belongs to the histone deacetylase family. HD Type 1 subfamily.
created [InstanceEdit:6787061] Amarasinghe, Vindhya, 2015-07-10
databaseName UniProt
dbId 6786896
description
  • recommendedName: fullName evidence="8"Histone deacetylase 1 shortName evidence="8"OsHDAC1 ecNumber evidence="1"3.5.1.98
displayName UniProt:Q7Y0Y8 Os06g0583400
geneName
  • Os06g0583400
  • P0498C03.28-1
  • HDAC1
  • HDA702
  • LOC_Os06g38470
identifier Q7Y0Y8
isSequenceChanged false
keyword
  • Alternative splicing
  • Chromatin regulator
  • Hydrolase
  • Metal-binding
  • Nucleus
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Zinc
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • HDAC1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HDAC1_ORYSJ
  • Q5VP94
sequenceLength 518
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q7Y0Y8