UniProt:Q6YV23 CARA

chain
  • transit peptide:1-50
  • chain:51-446
checksum E529103D9D4D3A47
comment
  • FUNCTION Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.CATALYTIC ACTIVITY hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)CATALYTIC ACTIVITY L-glutamine + H2O = L-glutamate + NH4(+)PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.SUBUNIT Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.SUBCELLULAR LOCATION Belongs to the CarA family.SEQUENCE CAUTION Intron retention.
created [InstanceEdit:5633271] Amarasinghe, Vindhya, 2014-10-31
databaseName UniProt
dbId 5633267
description
  • recommendedName: Carbamoyl phosphate synthase small chain, chloroplastic ecNumber: 6.3.5.5 alternativeName: Carbamoyl phosphate synthetase glutamine chain
displayName UniProt:Q6YV23 CARA
geneName
  • CARA
  • Os02g0708100
  • LOC_Os02g47850
  • OSJNBb0060O16.25
identifier Q6YV23
isSequenceChanged false
keyword
  • Amino-acid biosynthesis
  • Arginine biosynthesis
  • ATP-binding
  • Chloroplast
  • Glutamine amidotransferase
  • Ligase
  • Nucleotide-binding
  • Plastid
  • Pyrimidine biosynthesis
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • CARA
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CARA_ORYSJ
  • Q6YV24
  • Q8S3R8
sequenceLength 446
species [Species:186860] Oryza sativa
url http://purl.uniprot.org/uniprot/Q6YV23