UniProt:Q7XI96 BZR1

chain
  • chain:1-298
checksum 407B51633EF06C80
comment
  • FUNCTION Positive brassinosteroid-signaling protein. Mediates downstream brassinosteroid-regulated growth response and feedback inhibition of brassinosteroid (BR) biosynthetic genes (PubMed:17699623, PubMed:19220793). May act as transcriptional repressor by binding the brassinosteroid-response element (BREE) (5'-CGTG(T/C)G-3') in the promoter of DLT (AC Q9LWU9), another positive regulator of BR signaling (PubMed:19220793). Acts as a transcriptional repressor of LIC, a negative regulator of BR signaling, by binding to the BRRE element of its promoter. BZR1 and LIC play opposite roles in BR signaling and regulation of leaf bending (PubMed:22570626).SUBUNIT Interacts with GF14C (PubMed:17699623). Interacts with PUB24 (PubMed:30920691). Interacts with SMOS1 (PubMed:28100707).INTERACTION Brassinosteroid promotes nuclear localization, and binding to GF14C is required for cytoplasmic retention and efficient inhibition of BZR1 when brassinosteroid levels are low.INDUCTION Down-regulated by 24-epibrassinolide.PTM Phosphorylated on serine and threonine residues by GSK2 (PubMed:22685166). Dephosphorylated during response to brassinosteroid (PubMed:17699623, PubMed:22685166).PTM Ubiquitinated by PUB24 (PubMed:30920691). Ubiquitination leads to its subsequent degradation by the 26S proteasome, thus reducing sensitivity to brassinosteroid signaling (PubMed:30920691).MISCELLANEOUS Plants silencing BZR1 are dwarf with erect leaves, and have reduced brassinosteroid sensitivity and altered expression of brassinosteroid-responsive genes.SIMILARITY Belongs to the BZR/LAT61 family.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:5632076] Amarasinghe, Vindhya, 2014-10-28
databaseName UniProt
dbId 5632038
description
  • recommendedName: fullName evidence="10"Protein BZR1 homolog 1 shortName evidence="9"OsBZR1 alternativeName: fullName evidence="10"Protein BRASSINAZOLE-RESISTANT 1 homolog 1
displayName UniProt:Q7XI96 BZR1
geneName
  • BZR1
  • Os07g0580500
  • LOC_Os07g39220
  • OsJ_24880
  • P0453G03.22
identifier Q7XI96
isSequenceChanged false
keyword
  • Brassinosteroid signaling pathway
  • Cytoplasm
  • DNA-binding
  • Growth regulation
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9862192] Weiser, Joel, 2024-02-26
name
  • BZR1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BZR1_ORYSJ
  • A0A0P0X7Z8
  • Q0D559
sequenceLength 298
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q7XI96