UniProt:P0C587 Os10g0502400

chain
  • transit peptide:1-48
  • chain:49-537
checksum 51415C5525E3C640
comment
  • FUNCTION Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).CATALYTIC ACTIVITY (S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP(+) = L-glutamyl-tRNA(Glu) + NADPH + H(+)PATHWAY Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.SUBCELLULAR LOCATION During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA (By similarity).SIMILARITY Belongs to the glutamyl-tRNA reductase family.
created [InstanceEdit:4827073] D'Eustachio, P, 2013-10-29
databaseName UniProt
dbId 4827059
description
  • recommendedName: Glutamyl-tRNA reductase, chloroplastic shortName: GluTR ecNumber: 1.2.1.70
displayName UniProt:P0C587 Os10g0502400
geneName
  • Os10g0502400
  • LOC_Os10g35840
  • OSJNBa0078O01.14
  • OSJNBb0073N24.1
identifier P0C587
isSequenceChanged false
keyword
  • Chlorophyll biosynthesis
  • Chloroplast
  • NADP
  • Oxidoreductase
  • Plastid
  • Porphyrin biosynthesis
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • Os10g0502400
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HEM1_ORYSJ
  • A0A0P0XVV7
  • O48674
  • Q0IWL0
  • Q337F6
  • Q8LNE9
  • Q9FW00
sequenceLength 537
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/P0C587