UniProt:Q6L4R7 PP2C53

chain
  • chain:1-445
checksum E06D4D4A57E97FC1
comment
  • FUNCTION Protein phosphatase that acts as a negative regulator of abscisic acid (ABA) signaling. Involved in the regulation of root architecture development and drought resistance. Can dephosphorylate SAPK8 and SAPK10 in vitro. Together with PYL10, SAPK8 and SAPK10, may form an ABA signaling module involved in stress response.CATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateCOFACTOR Binds 2 magnesium or manganese ions per subunit.ACTIVITY REGULATION Repressed by abscisic acid-bound PYL1.SUBUNIT Interacts with PYL10, SAPK8 and SAPK10. Binding to PYL10 is dependent on the presence of abscisic acid (ABA) (PubMed:26491145). Interacts with PYL3, PYL5, PYL9 and PYL10. Binding to PYL9 and PYL10 is dependent on the presence of ABA (PubMed:26362328).SUBCELLULAR LOCATION Treatment with abscisic acid (ABA) reduces the nuclear localization and enhances the cytosolic localization.ALTERNATIVE PRODUCTS Expressed in leaf blades, leaf sheaths and lamina joints. Expressed at low levels in roots, stems, flowers and panicles.INDUCTION Not induced by abscisic acid (ABA).MISCELLANEOUS Plants overexpressing PP2C53 are insensitive to abscisic acid (ABA), exhibit altered stomatal density and root architecture, and are hypersensitive to drought stress.SIMILARITY Belongs to the PP2C family.
created [InstanceEdit:3899386] Amarasinghe, V, 2013-07-15
databaseName UniProt
dbId 3899378
description
  • recommendedName: fullName evidence="8"Protein phosphatase 2C 53 shortName evidence="6"OsPP2C53 ecNumber evidence="4"3.1.3.16 alternativeName: fullName evidence="8"ABI1-like protein 2 shortName evidence="7"OsABI-LIKE2 shortName evidence="7"OsABIL2
displayName UniProt:Q6L4R7 PP2C53
geneName
  • PP2C53
  • ABIL2
  • Os05g0592800
  • LOC_Os05g51510
  • OsJ_018965
  • OsJ_19760
  • P0663C08.11
identifier Q6L4R7
isSequenceChanged false
keyword
  • Abscisic acid signaling pathway
  • Alternative splicing
  • Cytoplasm
  • Hydrolase
  • Magnesium
  • Manganese
  • Metal-binding
  • Nucleus
  • Protein phosphatase
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • PP2C53
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • P2C53_ORYSJ
  • B7EHS4
  • B9FJ05
sequenceLength 445
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6L4R7