UniProt:Q5JN42 Os01g0959800

chain
  • initiator methionine:
  • chain:2-624
  • chain:2-568
  • chain:569-624
checksum F1540411747C072D
comment
  • FUNCTION Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2COFACTOR Binds 1 pyruvoyl group covalently per subunit.PATHWAY Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.SUBUNIT Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.SUBCELLULAR LOCATION Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.SIMILARITY Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.SEQUENCE CAUTION Was originally thought to correspond to two different genes.SEQUENCE CAUTION Was originally thought to correspond to two different genes.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162588
description
  • recommendedName: fullName evidence="3"Phosphatidylserine decarboxylase proenzyme 2 ecNumber evidence="3"4.1.1.65 component recommendedName: fullName evidence="3"Phosphatidylserine decarboxylase 2 beta chain /component component recommendedName: fullName evidence="3"Phosphatidylserine decarboxylase 2 alpha chain /component
displayName UniProt:Q5JN42 Os01g0959800
geneName
  • Os01g0959800
  • LOC_Os01g72940
  • PSD2
  • P0401G10.19
identifier Q5JN42
isSequenceChanged false
keyword
  • Calcium
  • Decarboxylase
  • Endoplasmic reticulum
  • Lipid biosynthesis
  • Lipid metabolism
  • Lyase
  • Membrane
  • Metal-binding
  • Phospholipid biosynthesis
  • Phospholipid metabolism
  • Pyruvate
  • Reference proteome
  • Repeat
  • Vacuole
  • Zymogen
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • PSD2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSD2_ORYSJ
  • Q0JFV3
  • Q5JN41
sequenceLength 624
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q5JN42