UniProt:Q6EPN6 ISPF

chain
  • transit peptide:1-43
  • chain:44-222
checksum E2177B22E4AFCC72
comment
  • FUNCTION Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP (Probable). Is essential for chloroplast development (PubMed:29143298).CATALYTIC ACTIVITY 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMPCOFACTOR Binds 1 divalent metal cation per subunit.PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.SUBUNIT Homotrimer.SUBCELLULAR LOCATION Expressed in roots, leaves, stems, leaf sheaths and young panicles.INDUCTION Induced by jasmonate, copper, UV and chitin oligosaccharide elicitor.SIMILARITY Belongs to the IspF family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162547
description
  • recommendedName: fullName evidence="8"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic shortName evidence="6"MECDP-synthase shortName evidence="8"MECPS shortName evidence="8"MECS ecNumber evidence="9"4.6.1.12
displayName UniProt:Q6EPN6 ISPF
geneName
  • ISPF
  • MCS
  • Os02g0680600
  • LOC_Os02g45660
  • P0663F07.27
identifier Q6EPN6
isSequenceChanged false
keyword
  • Chloroplast
  • Isoprene biosynthesis
  • Lyase
  • Metal-binding
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • ISPF
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ISPF_ORYSJ
  • A0A0N7KFV8
  • Q0DYN3
sequenceLength 222
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6EPN6