UniProt:Q7G065 AGPL2

chain
  • chain:1-518
checksum F32383BA0A3BBFAC
comment
  • FUNCTION Involved in synthesis of starch. Catalyzes the synthesis of ADP-glucose, a molecule that serves as an activated glycosyl donor for alpha-1,4-glucan synthesis. Essential for starch synthesis in seed endosperm (PubMed:17406793, PubMed:24747952, PubMed:27957808, Ref.13). Is essential for both catalytic and allosteric regulatory properties of the cytosolic heterotetramer enzyme (PubMed:24747952).CATALYTIC ACTIVITY alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphateACTIVITY REGULATION Activated by 3'phosphoglycerate, inhibited by orthophosphate. Allosteric regulation. Inhibited by inorganic phosphate (Pi).PATHWAY Glycan biosynthesis; starch biosynthesis.SUBUNIT Heterotetramer composed of two small and two large subunits.SUBCELLULAR LOCATION Expressed in developing seeds from 10 to 20 days after flowering (DAF).DISRUPTION PHENOTYPE Shrunken seed endosperm due to a strong reduction in starch synthesis.SIMILARITY Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162459
description
  • recommendedName: fullName evidence="11"Glucose-1-phosphate adenylyltransferase large subunit 2, cytosolic shortName evidence="7"OsAGPL2 shortName evidence="6"OsAPL2 ecNumber evidence="3"2.7.7.27 alternativeName: fullName evidence="11"ADP-glucose pyrophosphorylase AGPL2 alternativeName: fullName evidence="11"ADP-glucose synthase AGPL2 alternativeName: fullName evidence="10"Protein FLOURY ENDOSPERM 6 alternativeName: fullName evidence="9"Protein GRAIN INCOMPLETE FILLING 2 alternativeName: fullName evidence="8"Protein SHRUNKEN 1
displayName UniProt:Q7G065 AGPL2
geneName
  • AGPL2
  • APL2
  • FLO6
  • GIF2
  • SHR1
  • Os01g0633100
  • LOC_Os01g44220
  • P0663E10.9
identifier Q7G065
isSequenceChanged false
keyword
  • Allosteric enzyme
  • ATP-binding
  • Cytoplasm
  • Nucleotide-binding
  • Nucleotidyltransferase
  • Reference proteome
  • Starch biosynthesis
  • Transferase
modified [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
name
  • AGPL2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GLGL2_ORYSJ
  • B8XEC7
  • Q5VNT5
  • Q9ARI0
sequenceLength 518
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q7G065