UniProt:Q0JC10 SAMDC

chain
  • chain:1-77
  • chain:78-398
checksum BC24F359962F8655
comment
  • CATALYTIC ACTIVITY S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2COFACTOR Binds 1 pyruvoyl group covalently per subunit.PATHWAY Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.PTM Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (By similarity).SIMILARITY Belongs to the eukaryotic AdoMetDC family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162376
description
  • recommendedName: S-adenosylmethionine decarboxylase proenzyme shortName: AdoMetDC shortName: SAMDC ecNumber: 4.1.1.50 component recommendedName: S-adenosylmethionine decarboxylase alpha chain /component component recommendedName: S-adenosylmethionine decarboxylase beta chain /component
displayName UniProt:Q0JC10 SAMDC
geneName
  • SAMDC
  • Os04g0498600
  • LOC_Os04g42090
  • OsJ_004076
  • OSJNBa0029H02.4
  • OSJNBa0067K08.23
identifier Q0JC10
isSequenceChanged false
keyword
  • Autocatalytic cleavage
  • Decarboxylase
  • Lyase
  • Polyamine biosynthesis
  • Pyruvate
  • Reference proteome
  • S-adenosyl-L-methionine
  • Schiff base
  • Spermidine biosynthesis
  • Zymogen
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • SAMDC
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DCAM_ORYSJ
  • A2ZZV4
  • O24215
  • O81269
  • Q56CX9
  • Q7XU78
  • Q7XUL0
  • Q9SC65
sequenceLength 398
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q0JC10