UniProt:Q5Z8V9 HEMB

chain
  • transit peptide:1-45
  • chain:46-426
checksum 04A43F6AE5E51DAF
comment
  • FUNCTION Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).CATALYTIC ACTIVITY 2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)COFACTOR Binds 2 magnesium ions per monomer. The first magnesium ion is required for catalysis. The second functions as allosteric activator.PATHWAY Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.SUBUNIT Homooctamer.SUBCELLULAR LOCATION Belongs to the ALAD family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162310
description
  • recommendedName: Delta-aminolevulinic acid dehydratase, chloroplastic shortName: ALADH ecNumber: 4.2.1.24 alternativeName: Porphobilinogen synthase
displayName UniProt:Q5Z8V9 HEMB
geneName
  • HEMB
  • Os06g0704600
  • LOC_Os06g49110
  • OsJ_22561
  • P0018H04.2
identifier Q5Z8V9
isSequenceChanged false
keyword
  • Allosteric enzyme
  • Chlorophyll biosynthesis
  • Chloroplast
  • Heme biosynthesis
  • Lyase
  • Magnesium
  • Metal-binding
  • Plastid
  • Porphyrin biosynthesis
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • HEMB
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HEM2_ORYSJ
  • A0A0P0X108
sequenceLength 426
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q5Z8V9