UniProt:Q10T43 Os03g0101900

chain
  • transit peptide:1-21
  • chain:22-438
  • chain:22-386
  • chain:387-438
checksum B706B76F9965EABC
comment
  • FUNCTION Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2COFACTOR Binds 1 pyruvoyl group covalently per subunit.PATHWAY Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.SUBUNIT Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.SUBCELLULAR LOCATION Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.PTM Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.SIMILARITY Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1162127
description
  • recommendedName: fullName evidence="1"Phosphatidylserine decarboxylase proenzyme 1, mitochondrial ecNumber evidence="1"4.1.1.65 component recommendedName: fullName evidence="1"Phosphatidylserine decarboxylase 1 beta chain /component component recommendedName: fullName evidence="1"Phosphatidylserine decarboxylase 1 alpha chain /component
displayName UniProt:Q10T43 Os03g0101900
geneName
  • Os03g0101900
  • LOC_Os03g01216
  • PSD1
identifier Q10T43
isSequenceChanged false
keyword
  • Decarboxylase
  • Lipid biosynthesis
  • Lipid metabolism
  • Lyase
  • Membrane
  • Mitochondrion
  • Mitochondrion inner membrane
  • Phospholipid biosynthesis
  • Phospholipid metabolism
  • Pyruvate
  • Reference proteome
  • Transit peptide
  • Transmembrane
  • Transmembrane helix
  • Zymogen
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • PSD1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSD1_ORYSJ
  • A0A0P0VRT9
sequenceLength 438
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q10T43