UniProt:Q2QRX6 Os12g0446900

chain
  • chain:1-494
checksum 1F7F2D5162109A1B
comment
  • FUNCTION Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).CATALYTIC ACTIVITY (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)CATALYTIC ACTIVITY dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMPPATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.SIMILARITY In the N-terminal section; belongs to the dihydrofolate reductase family.SIMILARITY In the C-terminal section; belongs to the thymidylate synthase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1161403
description
  • recommendedName: Putative bifunctional dihydrofolate reductase-thymidylate synthase shortName: DHFR-TS domain recommendedName: Dihydrofolate reductase ecNumber: 1.5.1.3 /domain domain recommendedName: Thymidylate synthase ecNumber: 2.1.1.45 /domain
displayName UniProt:Q2QRX6 Os12g0446900
geneName
  • Os12g0446900
  • LOC_Os12g26060
identifier Q2QRX6
isSequenceChanged false
keyword
  • Methyltransferase
  • Multifunctional enzyme
  • NADP
  • Nucleotide biosynthesis
  • One-carbon metabolism
  • Oxidoreductase
  • Reference proteome
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • Os12g0446900
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DRTS_ORYSJ
sequenceLength 494
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q2QRX6