UniProt:P48642 GRC2

chain
  • chain:1-496
checksum A27FEE5D847F97F6
comment
  • FUNCTION Maintains high levels of reduced glutathione in the cytosol.CATALYTIC ACTIVITY 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)COFACTOR Binds 1 FAD per subunit.SUBCELLULAR LOCATION The active site is a redox-active disulfide bond.SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1161157
description
  • recommendedName: Glutathione reductase, cytosolic shortName: GR shortName: GRase ecNumber: 1.8.1.7
displayName UniProt:P48642 GRC2
geneName
  • GRC2
  • RGRC2
  • Os02g0813500
  • LOC_Os02g56850
  • OJ1293_E04.4-1
  • OsJ_08842
  • OSJNBa0053L11.26-1
identifier P48642
isSequenceChanged false
keyword
  • Cytoplasm
  • Disulfide bond
  • FAD
  • Flavoprotein
  • NADP
  • Oxidoreductase
  • Redox-active center
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • GRC2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GSHRC_ORYSJ
  • A0A0P0VR51
  • Q0DWI9
  • Q6K3E8
  • Q8GRV3
  • Q9ZNS8
sequenceLength 496
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/P48642