UniProt:Q6AVG6 ISPH

chain
  • transit peptide:1-31
  • chain:32-459
checksum 7134DF044F1814DD
comment
  • FUNCTION Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development.CATALYTIC ACTIVITY isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)CATALYTIC ACTIVITY dimethylallyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)COFACTOR Binds 1 [4Fe-4S] cluster per subunit.PATHWAY Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.SUBUNIT Homodimer.SUBCELLULAR LOCATION Induced by jasmonate, copper, UV and chitin oligosaccharide elicitor.SIMILARITY Belongs to the IspH family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1160976
description
  • recommendedName: fullName evidence="6"4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic ecNumber evidence="3"1.17.7.4
displayName UniProt:Q6AVG6 ISPH
geneName
  • ISPH
  • Os03g0731900
  • LOC_Os03g52170
  • OSJNBa0079G12.18
identifier Q6AVG6
isSequenceChanged false
keyword
  • 4Fe-4S
  • Chloroplast
  • Iron
  • Iron-sulfur
  • Isoprene biosynthesis
  • Metal-binding
  • Oxidoreductase
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • ISPH
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ISPH_ORYSJ
  • A0A0P0W2J7
sequenceLength 459
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6AVG6