UniProt:Q8RU95 4CLL6

chain
  • chain:1-598
checksum 56B7C37D12A686CB
comment
  • FUNCTION Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.CATALYTIC ACTIVITY (E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphateCATALYTIC ACTIVITY (E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)COFACTOR Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
databaseName UniProt
dbId 1160741
description
  • recommendedName: 4-coumarate--CoA ligase-like 6 ecNumber evidence="1"6.2.1.12
displayName UniProt:Q8RU95 4CLL6
geneName
  • 4CLL6
  • Os01g0901600
  • LOC_Os01g67540
  • B1065G12.10
  • P0551C06.10
identifier Q8RU95
isSequenceChanged false
keyword
  • ATP-binding
  • Ligase
  • Magnesium
  • Nucleotide-binding
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • 4CLL6
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 4CLL6_ORYSJ
  • A0A0P0VBX5
sequenceLength 598
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q8RU95