UniProt:Q8W1L6 MFP

chain
  • chain:1-726
checksum AFB6E3D2AD02E03E
comment
  • FUNCTION Multifunctional enzyme involved in fatty acid beta-oxidation. Also binds to RNA and microtubules. Possible role in subcellular mRNA localization and RNA-cytoskeleton interactions.CATALYTIC ACTIVITY a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2OCATALYTIC ACTIVITY a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2OCATALYTIC ACTIVITY a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoACATALYTIC ACTIVITY (3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoACATALYTIC ACTIVITY a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)PATHWAY Lipid metabolism; fatty acid beta-oxidation.SUBUNIT Monomer.SUBCELLULAR LOCATION The epimerase and isomerase activities are contained in the N-terminal region while the dehydrogenase activity is in the C-terminal region.SIMILARITY In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.SIMILARITY In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1160552
description
  • recommendedName: Peroxisomal fatty acid beta-oxidation multifunctional protein shortName: MFP domain recommendedName: Enoyl-CoA hydratase/3-2-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase ecNumber: 4.2.1.17 ecNumber: 5.1.2.3 ecNumber: 5.3.3.8 /domain domain recommendedName: 3-hydroxyacyl-CoA dehydrogenase ecNumber: 1.1.1.35 /domain
displayName UniProt:Q8W1L6 MFP
geneName
  • MFP
  • Os02g0274100
  • LOC_Os02g17390
  • P0413A11.18
identifier Q8W1L6
isSequenceChanged false
keyword
  • Cytoplasm
  • Cytoskeleton
  • Direct protein sequencing
  • Fatty acid metabolism
  • Isomerase
  • Lipid metabolism
  • Lyase
  • Microtubule
  • Multifunctional enzyme
  • NAD
  • Oxidoreductase
  • Peroxisome
  • Reference proteome
  • RNA-binding
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • MFP
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MFP_ORYSJ
  • Q0E238
  • Q336K1
  • Q6K7T9
sequenceLength 726
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q8W1L6