UniProt:Q0E079 RIBA2

chain
  • transit peptide:1-56
  • chain:57-553
checksum 173D0EF102FF34AA
comment
  • FUNCTION Involved in riboflavin biosynthesis. Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity).CATALYTIC ACTIVITY D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)CATALYTIC ACTIVITY GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)COFACTOR Binds 2 divalent metal cations per subunit. Magnesium or manganese.COFACTOR Binds 1 zinc ion per subunit.PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.SUBCELLULAR LOCATION In the N-terminal section; belongs to the DHBP synthase family.SIMILARITY In the C-terminal section; belongs to the GTP cyclohydrolase II family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1160446
description
  • recommendedName: Probable bifunctional riboflavin biosynthesis protein RIBA 2, chloroplastic shortName: OsRIBA2 domain recommendedName: 3,4-dihydroxy-2-butanone 4-phosphate synthase shortName: DHBP synthase ecNumber: 4.1.99.12 /domain domain recommendedName: GTP cyclohydrolase-2 ecNumber: 3.5.4.25 alternativeName: GTP cyclohydrolase II /domain
displayName UniProt:Q0E079 RIBA2
geneName
  • RIBA2
  • Os02g0572400
  • J023020F21
  • OsJ_07218
identifier Q0E079
isSequenceChanged false
keyword
  • Chloroplast
  • GTP-binding
  • Hydrolase
  • Lyase
  • Magnesium
  • Manganese
  • Metal-binding
  • Multifunctional enzyme
  • Nucleotide-binding
  • Plastid
  • Reference proteome
  • Riboflavin biosynthesis
  • Transit peptide
  • Zinc
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • RIBA2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RIBA2_ORYSJ
  • A0A0P0VKQ6
sequenceLength 553
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q0E079