UniProt:Q67W29 DAPB1

chain
  • transit peptide:1-14
  • chain:15-343
checksum 93D85B900A9C247A
comment
  • FUNCTION Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.SUBCELLULAR LOCATION Belongs to the DapB family.CAUTION Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1159839
description
  • recommendedName: Probable 4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic shortName: HTPA reductase 1 ecNumber: 1.17.1.8
displayName UniProt:Q67W29 DAPB1
geneName
  • DAPB1
  • Os02g0436400
  • LOC_Os02g24020
  • OJ1126_B05.33
  • OsJ_006340
  • OsJ_06538
identifier Q67W29
isSequenceChanged false
keyword
  • Amino-acid biosynthesis
  • Chloroplast
  • Diaminopimelate biosynthesis
  • Lysine biosynthesis
  • NAD
  • NADP
  • Oxidoreductase
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • DAPB1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DAPB1_ORYSJ
  • A3A6B8
  • B7EB68
sequenceLength 343
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q67W29