UniProt:Q6H6D2 HEMC

chain
  • signal peptide:1-24
  • chain:25-358
checksum 551C55AFC7AF3943
comment
  • FUNCTION Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.CATALYTIC ACTIVITY 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)COFACTOR Binds 1 dipyrromethane group covalently.PATHWAY Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.PATHWAY Porphyrin-containing compound metabolism; chlorophyll biosynthesis.SUBCELLULAR LOCATION The porphobilinogen subunits are added to the dipyrromethane group.SIMILARITY Belongs to the HMBS family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1159832
description
  • recommendedName: Porphobilinogen deaminase, chloroplastic shortName: PBG ecNumber: 2.5.1.61 alternativeName: Hydroxymethylbilane synthase shortName: HMBS alternativeName: Pre-uroporphyrinogen synthase
displayName UniProt:Q6H6D2 HEMC
geneName
  • HEMC
  • Os02g0168800
  • LOC_Os02g07230
  • OsJ_05540
  • P0669G09.15-1
  • P0669G09.15-2
identifier Q6H6D2
isSequenceChanged false
keyword
  • Alternative splicing
  • Chlorophyll biosynthesis
  • Chloroplast
  • Plastid
  • Porphyrin biosynthesis
  • Reference proteome
  • Signal
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • HEMC
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HEM3_ORYSJ
  • A0A0P0VF64
  • Q6H6D1
sequenceLength 358
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6H6D2