UniProt:Q9AWZ8 KPHMT1

chain
  • transit peptide:1-59
  • chain:60-364
checksum 3393C0A29F2B1512
comment
  • FUNCTION Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.CATALYTIC ACTIVITY 3-methyl-2-oxobutanoate + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolateCOFACTOR Binds 1 Mg(2+) ion per subunit.PATHWAY Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.SUBCELLULAR LOCATION Belongs to the PanB family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1159806
description
  • recommendedName: 3-methyl-2-oxobutanoate hydroxymethyltransferase 1, mitochondrial ecNumber: 2.1.2.11 alternativeName: Ketopantoate hydroxymethyltransferase 1
displayName UniProt:Q9AWZ8 KPHMT1
geneName
  • KPHMT1
  • PANB1
  • Os01g0225400
  • LOC_Os01g12560
  • P0443E07.6
  • P0492F05.15
identifier Q9AWZ8
isSequenceChanged false
keyword
  • Magnesium
  • Metal-binding
  • Mitochondrion
  • Pantothenate biosynthesis
  • Reference proteome
  • Transferase
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • KPHMT1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PANB1_ORYSJ
  • Q0JPF4
sequenceLength 364
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q9AWZ8