UniProt:Q0JA81 KSL2

chain
  • transit peptide:1-58
  • chain:59-819
checksum F96B6D13B90C8AD9
comment
  • FUNCTION Diterpene cyclase involved in jasmonic acid-dependent defense mechanisms in roots by mediating the biosynthesis of labdane-related diterpenoids (LRDs) natural products such as ent-beyerene, an antimicrobial compound (PubMed:25824047). Catalyzes the cyclization of ent-CDP into ent-beyerene as a major and ent-kaurene as a minor product (PubMed:25824047). May be involved in the catalysis of an early step of the gibberellin (GA) biosynthesis pathway (PubMed:23944972).CATALYTIC ACTIVITY ent-copalyl diphosphate = ent-beyerene + diphosphateCATALYTIC ACTIVITY ent-copalyl diphosphate = ent-kaur-16-ene + diphosphateCOFACTOR Binds 3 Mg(2+) ions per subunit.PATHWAY Secondary metabolite biosynthesis; terpenoid biosynthesis.SUBCELLULAR LOCATION Expressed in roots (PubMed:25824047). Highly expressed in stems, flowers and panicle (PubMed:23944972).INDUCTION Strongly induced in roots by methyl jasmonate (meJA) (PubMed:25824047). Induced by drought stress (PubMed:23944972).DOMAIN The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).DISRUPTION PHENOTYPE Severe dwarf phenotype with reduced shoot growth, reduced crown roots and growth of branch roots, abnormal leaf blade morphology, dark-green leaves, short and wide edges, leaf tips rounded and almost sterile seeds.SIMILARITY Belongs to the terpene synthase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1158992
description
  • recommendedName: fullName evidence="7"Ent-beyerene synthase KSL2, chloroplastic ecNumber evidence="5"4.2.3.229 alternativeName: fullName evidence="6 7"Ent-kaurene synthase-like 2 shortName evidence="6 7"OsKSL2 ecNumber evidence="5"4.2.3.19
displayName UniProt:Q0JA81 KSL2
geneName
  • KSL2
  • Os04g0612000
  • LOC_Os04g52240
  • OsJ_16127
  • OSJNBa0070C17.9
  • OSNPB_040612000
identifier Q0JA81
isSequenceChanged false
keyword
  • Chloroplast
  • Lyase
  • Magnesium
  • Metal-binding
  • Plant defense
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • KSL2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KSL2_ORYSJ
  • A0A0F7QZZ2
  • A0A0P0WEP9
  • A4KAG6
  • B9FCG1
  • Q7XLD9
sequenceLength 819
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q0JA81